Results 101 to 110 of about 91,363 (358)

Location, location, location: Variation in sensitivity to pain across the body

European Journal of Pain, 2016
AbstractBackgroundThere is evidence that sensitivity to noxious stimuli differs between the sexes and across the body, but few studies have investigated differences in the perception and experience of acute pain stimuli across the body in healthy individuals.MethodsWe recruited 52 healthy participants, aged 18–36 (50% men) and administered 39, 42 and ...
Tracy, Lincoln M., Georgiou-Karistianis, Nellie, Gibson, Stephen J., Giummarra, Melita J.   +3 more
openaire   +5 more sources

Laser Engineering of HfN‐Based Nanoparticles for Safe NIR‐I Photothermal and X‐ray Enhancing Cancer Therapies

Advanced Functional Materials, EarlyView.
In this study, we produced HfN‐based nanoparticles via femtosecond laser ablation in acetone. The nanoparticles exhibit a red‐shifted plasmonic resonance in the NIR‐I window, colloidal stability after coating with polyethyleneglycol, and excellent biocompatibility. The photothermal and X‐ray sensitization therapeutic effects were demonstrated for tumor
Julia S. Babkova, Ivan V. Zelepukin, Lyubov V. Gorelik, Anton L. Popov, Andrei I. Pastukhov, Gleb V. Tikhonowski, Maxim S. Savinov, Danil D. Kolmanovich, Nikita A. Pivovarov, Alina Yu. Kapitannikova, Anton A. Popov, Anna S. Sogomonyan, Vsevolod A. Skribitsky, Aziz B. Mirkasymov, Andrei V. Kabashin, Sergey M. Deyev   +15 more
wiley   +1 more source

Paradoxical Glucose-Sensitizing yet Proinflammatory Effects of Acute ASP Administration in Mice

Mediators of Inflammation, 2013
Acylation stimulating protein (ASP) is an adipokine derived from the immune complement system, which stimulates fat storage and is typically increased in obesity, type 2 diabetes, and cardiovascular disease. Using a diet-induced obesity (DIO) mouse model,
Alexandre Fisette, Pegah Poursharifi, Katerina Oikonomopoulou, Mercedes N. Munkonda, Marc Lapointe, Katherine Cianflone   +5 more
doaj   +1 more source

Step-by-step Individual Intensification of Therapy for Type 2 Diabetes Mellitus. What is Further Choice after Metformin? (Literature Review)

Mìžnarodnij Endokrinologìčnij Žurnal, 2015
Metformin — first-line drug for the treatment of diabetes mellitus (DM) type 2, the use of which reduces the progression of carbohydrate metabolism disorders and helps to reduce mortality rates.
І.V. Pankiv
doaj   +1 more source

4D‐Printable Poly(Thio)urethane Photoresins With Reactive Oxygen Species Responsiveness and Anti‐Inflammatory Functionality

Advanced Functional Materials, EarlyView.
This work introduces UV‐curable poly(thio)urethane (PSU) thermosets as 4D printable scaffolds responsive to oxidative stress. PSU networks with 100 wt.% polypropylene glycol (PPG) effectively suppress inflammatory markers in microglial cells to basal values.
Xabier Lopez de Pariza, Lolita Arévalo‐Lagos, Louise Breloy, Oihane Varela, Aitor Larrañaga, Juan F. Cadavid‐Vargas, Olaia Garagarza‐Goienetxea, Melissa Moya‐Granados, Vanessa Bagnarello, Haritz Sardon, Miryam Criado‐Gonzalez   +10 more
wiley   +1 more source

‘We Just Do What the Teacher Says’—Students’ Perspectives on Participation in ‘Inclusive’ Physical Education Classes

Education Sciences
To date, it remains unclear how students position themselves within the tension between participation, achievement, and body norms in physical education (PE), as well as what role participatory structures play in this process.
Bianca Sandbichler, Christoph Kreinbucher-Bekerle, Sebastian Ruin   +2 more
doaj   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Golden era of radiosensitizers

Frontiers in Veterinary Science
The past 30 years have brought undeniable progress in medicine, biology, physics, and research. Knowledge of the nature of the human body, diseases, and disorders has been constantly improving, and the same is true regarding their treatment and diagnosis.
Jana Cizkova, Ondrej Jan Dolezal, Vojtech Buchta, Jan Pospichal, Vit Blanar, Zuzana Sinkorova, Anna Carrillo   +6 more
doaj   +1 more source

“Peeling an onion”: layering as a methodology to promote embodied perspectives in video analysis

Video Journal of Education and Pedagogy, 2018
This article proposes a methodological framework for analyzing video by adopting an embodied perspective. In order to deal with researching the complexity of human interaction that has been captured on video, structured ways for analysis are needed.
Liv Kondrup Kristensen
doaj   +1 more source

A Human‐Based Skin‐Lymphoreticular Model‐on‐Chip to Emulate Inflammatory Skin Conditions

Advanced Healthcare Materials, EarlyView.
A human‐based lymphoreticular (LR) model was developed through guided self‐assembly and integrated in a skin‐lymphoreticular co‐culture in a microfluidic organ‐on‐chip to mimic interactions between skin and its draining lymph nodes. The human‐based skin‐lymphoreticular model resembles a minimally functional unit that allows to study interactions ...
Zheng Tan, Partho Protim Adhikary, Dana Wörz, Sarah Hedtrich   +3 more
wiley   +1 more source