Results 91 to 100 of about 1,430,130 (241)
Sensor fault diagnosis method based on fractal dimension
, 2013 The development of automation technology has opened a new field - sensor fault diagnosis. Sensor is the source and foundation of information, once the sensor faults occur, which will lead to the degradation of automation system's performance, even ...
Liu JG(刘金国) +7 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Real-Time Fault Diagnosis for Hydraulic System Based on Multi-Sensor Convolutional Neural Network
SensorsThis paper proposed a real-time fault diagnostic method for hydraulic systems using data collected from multiple sensors. The method is based on a proposed multi-sensor convolutional neural network (MS-CNN) that incorporates feature extraction, sensor ...
Haohan Tao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Topology control in Heterogeneous Wireless Sensor Network [PDF]
, 2016 Topology of a Wireless Sensor Network determines the connectivity of the wireless network and topology Control is the important technique of extending network lifetime while preserving network connectivity.
Deshmukh, Prashant, Dandekar, Deepak R
core
Online Fault-Tolerant Onboard Aeroengine Model Tuning Structure
International Journal of Aerospace Engineering, 2016 Online onboard aeroengine models (OBEMs) have been widely used in health management, fault diagnostics, and fault-tolerant control. A mismatch between the OBEM and the actual engine may be caused by a variety of factors such as health degradation or ...
Shuiting Ding +3 more
doaj +1 more source