Results 101 to 110 of about 74,884 (346)

Expanding the SIAH1‐Associated Phenotypic Spectrum: Insights From Loss‐of‐Function Variants

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT SIAH1 encodes for a RING‐type E3 ubiquitin ligase involved in protein ubiquitination. More specifically, it positively regulates Wnt signaling through promoting the accumulation of β‐catenin and mediates ubiquitination and degradation of Akt3 in neural development.
Liza Douiev, Paula Fernandez Alvarez, Marika Frank, Lucy Hanington, Trevor L. Hoffman, Mira B. Irons, Jenny Kim, Akash Kumar, Amaia Lasa‐Aranzasti, Diana Le Duc, Helen Livesey, Oliver Murch, Deborah Shears, Brandon K. Walther, Tamar Harel   +14 more
wiley   +1 more source

Otologic and vestibular symptoms in COVID‐19: A scoping review

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 8, Issue 4, Page 287-296, December 2022., 2022
Abstract Background Otologic and vestibular symptoms have been seen in patients confirmed to have COVID‐19 disease. Further discussion of these symptoms may provide insight into short‐ and long‐term management for these patients. Objective The aim of this review was to describe the otologic and vestibular symptoms that present in patients with COVID‐19.
Kimberly Mae C. Ong, Teresa Luisa G. Cruz   +1 more
wiley   +1 more source

Perfil dos limiares audiométricos e curvas timpanométricas de idosos Profile of audiometric thresholds and tympanometric curve of elderly patients

Brazilian Journal of Otorhinolaryngology, 2010
OBJETIVO: Traçar o perfil audiológico dos idosos atendidos em uma clínica escola da cidade de Belo Horizonte. MÉTODOS: Foram analisados todos os prontuários de pacientes que realizaram avaliação audiológica no período de Abril de 2004 a Agosto de 2007 em
Tatiana Marques Guerra, Lucimar Pires Estevanovic, Marcela de Ávila Meira Cavalcante, Rafaela Carolina Lopez Silva, Izabel Cristina Campolina Miranda, Victor Gandra Quintas   +5 more
doaj   +1 more source

Nasal manifestations in granulomatosis with polyangiitis: a case report and review of the literature [PDF]

, 2018
Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides of medium and small arteries, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract with coexist ...
D'AGUANNO, VITTORIO, DE VINCENTIIS, Marco, FALASCA, VINCENZO, GRECO, Antonio, RALLI, MASSIMO, TURCHETTA, Rosaria   +5 more
core   +1 more source

Vestibular and cochlear dysfunction in aging: Two sides of the same coin?

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 8, Issue 4, Page 308-314, December 2022., 2022
Abstract Objective Nonspecific complaints of hearing loss, vertigo, imbalance, and instability, without a defined etiology, are very prevalent in the elderly population, with a great impact on morbidity and mortality in this age group. The objectives of this study were to verify whether there is age‐related vestibular dysfunction and to test the ...
Cátia Azevedo, Sérgio Vilarinho, Ana Sousa Menezes, Fernando Milhazes Mar, Luís Dias   +4 more
wiley   +1 more source

Clinical features and analysis of deafness genes in 2 patients from a Chinese family with MYH9 disorder

Di-san junyi daxue xuebao, 2019
Objective To investigate the clinical features of 2 deafness patients from a family with MYH9 disorder, and search the candidate genes related to deafness for mutation sites in this family. Methods Their detailed medical histories were surveyed. Physical
CHEN Yinyi, ZHANG Ying'ai, GAO Xin
doaj   +1 more source

Animal models of human herpesvirus infection

Animal Models and Experimental Medicine, EarlyView.
Human herpesvirus can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing.
Ziqing Jia, Dong Zhang, Lin Zhu, Jing Xue   +3 more
wiley   +1 more source

Response: Aortic Stiffness in Patients with Deep and Lobar Intracerebral Hemorrhage: Role of Antihypertensive Drugs and Statins [PDF]

Journal of Stroke, 2015
Maurizio Acampa, Francesca Guideri, Rossana Tassi, Giuseppe Martini   +3 more
doaj   +1 more source

Patient satisfaction after auditory implant surgery. ten-year experience from a single implanting unit center [PDF]

, 2016
Conclusions: The satisfaction rate of the subjects with an auditory implant appears strictly related to the resulting auditory improvement, and the surgical variables would play a prevailing role in respect to the esthetic factors.
Atturo, Francesca, Barbara, Maurizio, Bianchi, Alessandra, Filippi, Chiara, Monini, Simonetta, Talamonti, Rita   +5 more
core   +1 more source

A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T‐tubule pH regulation

Developmental Dynamics, EarlyView.
Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel, Maya Silver, Aaron H. Wasserman, Samantha Rea, Charles C. Hong, Charles H. Williams   +5 more
wiley   +1 more source