Results 171 to 180 of about 87,827 (343)

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

Single‐Nucleus Transcriptomics Uncovers Xaf1‐Driven PANoptosis as a Therapeutic Target in Aminoglycoside‐Induced Hearing Loss

Cell Proliferation, EarlyView.
Neomycin induces increased expression of Xaf1 in cochlear HCs, triggering PANoptosis, which encompasses pyroptosis, apoptosis and necroptosis (left). Targeted Xaf1 knockdown in HCs through gene therapy can significantly inhibit the occurrence of PANoptosis in HCs (right).
Xinlin Wang, Hairong Xiao, Jiheng Wu, Yanqin Lin, Yiheng Ao, Zixuan Ye, Xin Tan, Fanliang Kong, Xin Chen, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

"An Unusual Case of Bilateral Sudden Mixed Hearing Loss with Complete Remission": A Case Report and Pathophysiological Considerations. [PDF]

Reports (MDPI)
Cornelia MG, Sarafoleanu C, Radu L, Musat O, Tanase I.   +4 more
europepmc   +1 more source

Lower risk of cardiovascular events in patients initiated on semaglutide 2.4 mg in the real‐world: Results from the SCORE study (Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity in the Real World)

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims In this first interim analysis of the SCORE study, we investigated the risk of major adverse cardiovascular events (MACE) among individuals with atherosclerotic cardiovascular disease (ASCVD) and overweight/obesity but without diabetes who initiated semaglutide 2.4 mg in real‐world settings.
Kim G. Smolderen, Carlos Mena‐Hurtado, Zhenxiang Zhao, Wojciech Michalak, Mads Faurby, B. Gabriel Smolarz, Mikhail N. Kosiborod, Jinlin Song, Yan Chen, Joanna Boland, Michael G. Nanna   +10 more
wiley   +1 more source

Teprotumumab and sensorineural hearing loss: a propensity score-matched retrospective cohort study. [PDF]

Endocr Connect
Barnett MJL, Lam J, Jara-Tantoco MN, Casipit C, Eidbo S, Anastasopoulou C.   +5 more
europepmc   +1 more source

Caloric responses of the unilateral sensorineural-hearing-impaired children.

, 1979
Hiroya Yamaguchi, Toshiki Manabe, Tomoyuki Yamada, Soji Izumi, Kazuo Kujirai, Yutaka Yoshimoto   +5 more
openalex   +2 more sources

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Association Between Gastroesophageal Reflux Disease, Barrett's Esophagus and Ear Disorders: A Mendelian Randomization Study. [PDF]

J Multidiscip Healthc
Zhao W, Hao XR, Zhao HL, Ma YS, Li HX, Yang Q, Jiang JM, Bai HY.   +7 more
europepmc   +1 more source

Treatment of Sudden Sensorineural Hearing Loss

, 1978
Kiyotaka Murata
openalex   +2 more sources

Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro

Epilepsia, EarlyView.
Abstract Objective Autoimmune encephalitis (AE) is characterized by inflammatory processes in the central nervous system and frequently presents with seizures. Even though an ictogenic potential has been shown for some antibodies against neuronal surface antigens (NSAbs), AE pathophysiology is complex, and NSAbs‐independent mechanisms are likely to ...
Sara Prevosti, Alessio Passalacqua, Maria Cristina Regondi, Giada D'Ambrosio, Alessandra Morano, Michele Romoli, Giulia Maira, Flavio Villani, Pietro Mattioli, Diego Franciotta, Andrea Stabile, Marco de Curtis, Matteo Gastaldi, Francesco Deleo, Laura Librizzi   +14 more
wiley   +1 more source