Results 161 to 170 of about 75,481 (297)

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1522-1536, June 2026.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra   +4 more
wiley   +1 more source

Sensorineural Hearing Loss. [PDF]

open access: yesAnnals of Internal Medicine, 1971
G E W Wolstenholme, J Knight
openaire   +2 more sources

Adjunctive Hyperbaric Oxygen Therapy or Intratympanic Steroids in Sudden Sensorineural Hearing Loss?

open access: yesThe Laryngoscope, Volume 136, Issue 6, Page 2708-2718, June 2026.
Sudden sensorineural hearing loss is traditionally treated with steroids, either orally and/or via intratympanic injections, and hyperbaric oxygen treatment (HBOT) has resurged in popularity as an adjunctive therapy. The study has not found any additional treatment benefit with adjunctive concurrent HBOT; however, HBOT might be of value to patients ...
Jennifer L. Spiegel   +9 more
wiley   +1 more source

Screaming‐Induced Acute Noise Exposure During Pediatric Ear Procedures

open access: yesLaryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
Pediatric ENT procedures can generate rapid spikes in noise exposure due to patient screaming. Real‐time LAeq and cumulative dose measurements showed that recommended limits may be exceeded within minutes. These findings highlight acute acoustic risks for healthcare providers and the need for sensory‐adapted care environments.
Jun‐Ya Kita   +5 more
wiley   +1 more source

Seasonal effects on incidence and outcomes in idiopathic sudden sensorineural hearing loss. [PDF]

open access: yesFront Neurol
Ghantous J   +8 more
europepmc   +1 more source

Auditory Skills and Cognitive Functions in Adult Hearing Aid Users: A Cross‐Sectional Observational Comparison Study

open access: yesLaryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
ABSTRACT Objectives This study aimed to evaluate learning and memory functions in adults using hearing aids (HA) and examine their relationship with auditory skills. Methods The study group consisted of 32 adults aged 30–59 years with bilateral symmetrical sensorineural hearing loss who had used bilateral HA for at least 1 year.
Mert Kılıç   +2 more
wiley   +1 more source

Efficacy of a Quantitative Intra‐Operative Facial Nerve Continuous Monitoring System for Functional Preservation Following Intratemporal Facial Nerve Schwannoma Resection

open access: yesLaryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
We investigated the role of a continuous, quantitative intraoperative monitoring system in surgeries for facial nerve schwannomas, a rare tumor associated with a high risk of facial nerve dysfunction. By continuously stimulating the facial nerve and recording electromyographic responses in real time, the system enabled surgeons to detect subtle or ...
Makoto Hosoya   +7 more
wiley   +1 more source

Parental experience of whole genome sequencing for children with sensorineural hearing loss. [PDF]

open access: yesInt J Qual Stud Health Well-being
Elander J   +4 more
europepmc   +1 more source

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