Results 171 to 180 of about 2,878,732 (209)

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3017-3026, September 2026.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood, Sarah Bannister, Stephen Duffull, April Martinez, Sarath Ranganathan, Shivanthan Shanthikumar, Amanda Gwee   +6 more
wiley   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3002-3011, September 2026.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source

Identification of the Genomic Etiology of Unexplained Congenital Problems in Pediatric Patients: First Reported Case With Coffin–Siris Syndrome and Sialuria From India

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Coffin–Siris syndrome (CSS) (OMIM:614608) is a rare genetic disorder characterized by global developmental delay (GDD), speech impediment, coarse facial features, and hypoplastic or absent fifth fingernails/toenails. Genetic variants in the SMARCB1 gene are associated with CSS, benign tumors (schwannomas), and rhabdoid tumor predisposition ...
Aparna Bhanushali, Archana Kawalakatt, Smita Kulkarni, Preethi Nair, Ankita Mali, Ashlesha Pradhan, Anirvan Chatterjee   +6 more
wiley   +1 more source

A Rare Case of Auricular Angiolymphoid Hyperplasia With Eosinophilia Associated With Chronic Hearing Aid Use

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Evaluating external device‐related friction is essential when managing localized auricular vascular lesions. Clinicians should recognize that angiolymphoid hyperplasia with eosinophilia (ALHE) can arise secondary to chronic mechanical irritation and may present with minimal tissue eosinophilia.
Ayat Shawish, Maher Raslan, Reem Khabbaza, Mohammad Adib Houreih, Moatasem Hussein Al‐Janabi, Fouz Hassan   +5 more
wiley   +1 more source

Pontine Tegmental Cap Dysplasia Presenting With Global Developmental Delay and Vestibulocochlear Nerve Aplasia: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT PTCD should be considered in children with developmental delay and sensorineural hearing loss. MRI is crucial for identifying the characteristic dorsal “tegmental cap” and associated hindbrain anomalies. Vestibulocochlear nerve aplasia may explain severe hearing impairment in PTCD.
Khawar Bilal, Muhammad Owais Rao, Syed Muhammed Salman Hassan, Arnella Husenaj Tagani, Naila Nadeem, Sarim Hassan Shahab, Fazal Habib   +6 more
wiley   +1 more source

Vestibular Paroxysmia Coexisting With Meige Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT VP and MS are distinct clinical entities arising from the peripheral vestibular system and central extrapyramidal pathways, respectively. We report a rare case of a 69‐year‐old woman with coexistence of VP and MS. Individualized pharmacotherapy resolved vertigo and markedly improved blepharospasm.
Yanan Ding, Gendi Yin, Yongqiang Dai, Feng Qin, Xiangli Zeng, Qiling Huang, Yongqi Li   +6 more
wiley   +1 more source

Paeonol Alleviate Cisplatin‐ and Noise‐Induced Hearing Loss by Preserving Hair Cell Ribosome Biogenesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Paeonol protects against cisplatin‐ and noise‐induced hearing loss by mitigating oxidative damage and preserving protein homeostasis in cochlear hair cells, revealing a novel mechanism involving ribosome biogenesis. ABSTRACT Background Hearing loss primarily results from irreversible cochlear hair cell (HC) damage caused by factors such as noise, aging,
Minhui Xia, Tianshi Sun, Wenyu Hou, Yiyun Lou, Yunjie Li, Hua Jiang, Hui Chai, Jiaoyao Ma, Mingyu Xia   +8 more
wiley   +1 more source

Academic Performance Among Children With Sickle Cell Disease in Low‐ and Middle‐Income Countries: A Systematic Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aim Children with sickle cell disease (SCD) in low‐ and middle‐income countries (LMICs) face significant disease‐related challenges and socioeconomic status (SES) disparities that may negatively impact their academic performance. This systematic review synthesized existing evidence on academic performance among children with SCD
Shubaya K. Naggayi, Paul Bangirana, Simple Ouma, Mary Nyakato, Alison A. Kinengyere, Dickens Akena, Nancy S. Green, Richard Idro   +7 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Whole Exome Sequencing Identified a Novel Mutation in the LOXHD1 Gene in Consanguineous Iranian Families With Hearing Loss

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
Whole exome sequencing in a consanguineous Iranian family with autosomal recessive non‐syndromic hearing loss revealed a novel homozygous frameshift mutation, c.3713dupA (p.Asp1238Glufs*10), in the LOXHD1 gene. This mutation, located in exon 24, results in a premature stop codon and a truncated protein. Sanger sequencing confirmed co‐segregation of the
Solmaz Hassani Fard Katiraei, Milad Gholami, Mohsen Soosanabadi, Mona Entezam, Seyed Alireza Dastgheib   +4 more
wiley   +1 more source