Results 181 to 190 of about 2,878,732 (209)
An Optimized Diagnostic Approach for Adults With Suspected Inherited Metabolic Disorders
Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.A multidisciplinary strategy that integrates deep phenotyping with expert genetic interpretation substantially increases the likelihood of reaching a diagnosis in adults suspected of having an IMD. ABSTRACT Inherited metabolic disorders (IMDs) arise from defects in metabolic pathways essential for normal biochemical function.
Machteld M. Oud +12 more
wiley +1 more source
Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities
Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.The graphical abstract illustrates the context‐dependent therapeutic modulation of CLPP. Pharmacological CLPP activation has reached clinical application in cancer (black arrow), whereas reduced CLPP activity has shown beneficial effects experimentally in models of primary mitochondrial disease and metabolic syndrome, as well as cancer (grey arrows ...
Lea Isermann, Aleksandra Trifunovic
wiley +1 more source
Radiotherapy‐Induced Otitis Media With Effusion in Nasopharyngeal Carcinoma: A Meta‐Analysis
The Laryngoscope, Volume 136, Issue 9, Page 3718-3731, September 2026.This meta‐analysis of eight studies comprising 582 NPC patients provides the first quantitative synthesis of radiotherapy‐induced otitis media with effusion (OME), demonstrating a significant overall risk difference of 0.18 (95% CI: −0.06 to 0.42, p < 0.0001) in OME naive ears.
Nevin Yi Meng Chua +3 more
wiley +1 more source
Cochlear Implantation in Autoimmune Inner‐Ear Disease: Outcome and Patient‐Reported Benefit
The Laryngoscope, Volume 136, Issue 9, Page 3980-3989, September 2026.This study demonstrates that patients with secondary autoimmune inner‐ear disease (AIED) achieve significant improvements in speech perception and quality of life following cochlear implantation. Although AIED patients may show slightly lower performance in noisy environments compared to controls, their subjective hearing benefit converges with matched
Merete Hartmann +4 more
wiley +1 more source
Quantifying Soft‐Surgery in Cochlear Implantation: Multimodal Data From 30 International Specialists
The Laryngoscope, Volume 136, Issue 9, Page 3990-3997, September 2026.Objective data from 30 specialist cochlear implant surgeons showed that surgical handling strongly influences intracochlear mechanical stress during implantation. Surgeons with fewer than 50 lifetime insertions performed significantly worse than more experienced colleagues, while self‐assessment did not reflect objective performance in any group ...
Philipp Aebischer +3 more
wiley +1 more source
Disparities in Hearing Screening Practices in Minnesota Elementary Schools
The Laryngoscope, Volume 136, Issue 9, Page 4064-4071, September 2026.ABSTRACT Objective Identifying and addressing pediatric hearing loss is critical to supporting a child's development. School‐based hearing screening is a mainstay of timely identification of hearing loss. The objectives of this study were to characterize the current hearing screening practices in public, charter, and private elementary schools in ...
Autefeh Sajjadi +12 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan +9 more
wiley +1 more source
Advances in FGF/FGFR Signaling: Implications for Disease and Therapy
MedComm, Volume 7, Issue 9, September 2026.The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song +4 more
wiley +1 more source
Sudden Sensorineural Hearing Loss
Trends in Amplification, 2011 Sudden sensorineural hearing loss (SSNHL) is commonly encountered in audiologic and otolaryngologic practice. SSNHL is most commonly defined as sensorineural hearing loss of 30dB or greater over at least three contiguous audiometric frequencies ...
Pamela Roehm, Selena E Heman-Ackah
exaly +2 more sources