Results 101 to 110 of about 1,276,569 (292)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Sensory Products for Sensory Beings [PDF]
, 2019 The BA(Hons) Sustainable Product Design students engage with human-centred design research methods to understand more clearly the needs of users for whom a product is being designed for. The research seeks to expand the opportunities for co-design practice with audiences typically excluded from this process.
Andrews, Simon, Grace, Joanna
openaire
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
, 2020 Sensory maps depict the world as it is qualitatively experienced, drawing on alternative human sensory modalities to call attention to the more-than-visual sensory characteristics of place. Sensory maps combine aesthetics with empirically sensed datasets
McLean, K.
core
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
A Review of the Evidence for Sensory Interventions in the Treatment of ASD [PDF]
, 2012 It is estimated that Autism Spectrum Disorder (ASD) affects 1 in 88 children (CDC, 2012). Given this rapid and little understood increase in prevalence, the study of ASD and the search for effective treatments has become an area of intense interest ...
Smith, Jordan
core
Neural PlasticityParkinson’s disease (PD) is a neurodegenerative disorder characterised primarily by motor symptoms. However, non-motor symptoms (NMS) also substantially affect patients’ quality of life.
Shuang Hu, Jing Lei, Hao-Jun You
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source