Results 111 to 120 of about 1,103,473 (317)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Analysis of Sensory Properties in Foods: A Special Issue
, 2019 The sensory properties of foods are the most important reason people eat the foods they eat. What those properties are and how we best measure those properties are critical to understanding food and eating behavior.
Edgar Chambers
core +1 more source
Neural PlasticityParkinson’s disease (PD) is a neurodegenerative disorder characterised primarily by motor symptoms. However, non-motor symptoms (NMS) also substantially affect patients’ quality of life.
Shuang Hu, Jing Lei, Hao-Jun You
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Figuring Time by Space: Representing sensory motion in cortical maps [PDF]
, 2011 How does the brain represent sensory input? When stimuli move across sensor surfaces, such as a light source moving across the retina, sound moving between the ears, or contact moving over the skin, patterns of activation propagate across sheets of ...
Wilson, Stuart
core
SENSORY APPROACH TO MEASURE FRAGRANCE INTENSITY ON THE SKIN
, 2009 Sensory analysis is a precise and descriptive measuring technique to quantify human responses to stimuli. Odor, one of these stimuli, is basically the result of the interaction between a chemical stimulus and the olfactory receptor system, which can be ...
CORTEZ-PEREIRA, Claudia Silva +3 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Sensory Products for Sensory Beings [PDF]
, 2019 The BA(Hons) Sustainable Product Design students engage with human-centred design research methods to understand more clearly the needs of users for whom a product is being designed for. The research seeks to expand the opportunities for co-design practice with audiences typically excluded from this process.
Andrews, Simon, Grace, Joanna
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