Results 51 to 60 of about 39,538 (265)

The Burden of Managing Medicines for Older People With Sensory Impairment: An Ethnographic-Informed Study

Gerontology and Geriatric Medicine
Background: Older age is associated with increased prevalence of sensory impairment and use of medicines. Objectives: To explore the daily “medicine journey” of older people with sensory impairment.
Peter Fuzesi PhD, Kirsten Broadfoot PhD, Marilyn Lennon PhD, Sabrina Anne Jacob PhD, Leah Macaden PhD, Annetta Smith PhD, Tomas Welsh PhD, Margaret C. Watson PhD   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

HIV-Associated Vacuolar Myelopathy and HIV-Associated Dementia as the Initial Manifestation of HIV/AIDS

Case Reports in Infectious Diseases, 2019
HIV-associated vacuolar myelopathy (HIV-VM) is the most common cause of spinal disease in HIV/AIDS. HIV-VM causes progressive spastic paraparesis, sensory ataxia, and autonomic dysfunction.
Natalia Wuliji, Matthew J. Mandell, Jason M. Lunt, Adam Merando   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effect of processing aids on the quality of microwave foam-dried locust honey

Shipin yu jixie
ObjectiveTo investigate the effect of various processing aids on the quality of locust honey dried by microwave-assisted foam drying technology.MethodsSix processing aids, including egg white powder, soy protein isolate, maltodextrin, β-cyclodextrin ...
HAO Bingting, WANG Yingqiang, SHI Xixiong, ZHAO Hongxia   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Hearing and vision rehabilitation for people with dementia in five European countries (SENSE-Cog): a randomised controlled trial

The Lancet. Healthy Longevity
Summary: Background: The effect of hearing and vision difficulties on the risk of developing dementia and worsening outcomes in people already living with dementia is well established.
Iracema Leroi, MD, ProfPhD Christopher J Armitage, MD, Elizabeth M Camacho, PhD, Anna Pavlina Charalambous, PhD, J P Connelly, MSc, ProfPhD Fofi Constantinidou, MSc, Renaud David, PhD, ProfPhD Piers Dawes, PhD, ProfPhD Rachel A Elliott, PhD, Mark Hann, PhD, Alison Holden, MSc, Emma Hooper, MSc, Sean P Kennelly, PhD, Evangelia Kontogianni, MSc, ProfMD Brian A Lawlor, MSc, Julie Longobardi, MSc, Luke Paterson, MSc, Antonis M Politis, PhD, ProfPhD David Reeves, PhD, Christine Schwimmer, PhD, Chryssoula Thodi, PhD, Mark Worthington, MSc, Wai Kent Yeung, PhD, Eric Frison, PhD   +23 more
doaj   +1 more source