Results 41 to 50 of about 117,891 (311)

Cross-Modal Plasticity Results in Increased Inhibition in Primary Auditory Cortical Areas

Neural Plasticity, 2013
Loss of sensory input from peripheral organ damage, sensory deprivation, or brain damage can result in adaptive or maladaptive changes in sensory cortex.
Yu-Ting Mao, Sarah L. Pallas
doaj   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible. [PDF]

, 2018
To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we adopted a symptom-to-circuit approach in the Fmr1-knockout (Fmr1-/-) mouse model of Fragile X syndrome.
A Contractor, A Estes, A Mullard, Aditi Newadkar, Anubhuti Goel, B Zupan, Barbara Todisco, BN Armbruster, BV Atallah, C He, CA Runyan, Carlos Portera-Cailliau, CD Harvey, CE Robertson, CM Niell, Craig A. Erickson, CS Kogan, CS Kogan, CX He, Daniel A. Cantu, Diego de Alba, Ernest Pedapati, F Farzin, G Fata La, Gunvant R. Chaudhari, HA Zariwala, HK Kato, IS Knoth, J Akerboom, J Poort, Janna Guilfoyle, JC Cottam, JJ LeBlanc, JM Pakan, JP Hamm, JT Gonçalves, K Juczewski, K Plaisted, L Pinto, Lauren M. Schmitt, M Dipoppa, M Rifé, MT Arnett, Nazim Kourdougli, PJ Mineault, SB Hofer, SH Lee, SR Hooper, TA Pologruto, The Dutch-Belgian Fragile X Consortium., TW Chen, Y Gonchar, Y Zhang, ZV Guo   +53 more
core   +2 more sources

Sleep deprivation disrupts postural balance and sensorimotor integration: A combined psychophysiological–behavioral analysis

NeuroImage
Background: Sleep is crucial for optimal sensorimotor integration, a fundamental process enabling coordinated motor responses to sensory inputs. However, the neurophysiological mechanisms through which acute sleep deprivation impairs this integration ...
Lin Xu, Lei Peng, Xin An, Xiao Zhong, Yongcong Shao, Yuefang Dong, Weiwei Fu   +6 more
doaj   +1 more source

Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function

Cell Reports, 2019
Summary: This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input.
Alexander P.Y. Brown, Lee Cossell, Troy W. Margrie   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences

Neural Plasticity, 2012
The central nervous system architecture is highly dynamic and continuously modified by sensory experience through processes of neuronal plasticity. Plasticity is achieved by a complex interplay of environmental influences and physiological mechanisms ...
José Fernando Maya-Vetencourt, Nicola Origlia   +1 more
doaj   +1 more source

THE USE OF SENSORY DEPRIVATION IN PATIENTS WITH LONG-TERM CONSEQUENCES OF MILD COMBAT TRAUMATIC BRAIN INJURY

Медична наука України, 2020
Relevance. Traumatic brain injury (TBI) and its consequences often lead to disability, the progression of both the syndromes that arise after trauma and comorbid pathology.
V.O. Korshnyak, A.N. Stoyanov, I.O. Ostapenko, O.A. Hruzevskyi   +3 more
doaj   +1 more source