Results 91 to 100 of about 5,916,094 (333)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The pace and prognosis of peripheral sensory loss in advanced age: association with gait speed and falls

BMC Geriatrics, 2018
BackgroundPeripheral sensory loss is considered one of many risk factors for gait impairments and falls in older adults, yet no prospective studies have examined changes in touch sensation in the foot over time and their relationship to mobility and ...
L. Lipsitz, B. Manor, Daniel A. Habtemariam, I. Iloputaife, Junhong Zhou, T. Travison   +5 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Clinical characteristics of patients with diabetic peripheral neuropathy: a retrospective descriptive study

Frontiers in Clinical Diabetes and Healthcare
BackgroundDiabetic Peripheral Neuropathy (DPN) is a common complication of diabetes, particularly in regions with high disease prevalence, such as the United Arab Emirates (UAE).
Dana Rashwan, Bashair M. Mussa, Amena Sadiya, Rawoof Khan, Salah Abusnana, Salah Abusnana   +5 more
doaj   +1 more source

Sensory supplementation system based on electrotactile tongue biofeedback of head position for balance control [PDF]

, 2008
The present study aimed at investigating the effects of an artificial head position-based tongue-placed electrotactile biofeedback on postural control during quiet standing under different somatosensory conditions from the support surface.
Asai, Bach-y-Rita, Bach-y-Rita, Bernard-Demanze, Cenciarini, Danilov, Day, Fitzpatrick, Green, Horak, Inglis, Isableu, Jacques Demongeot, Kavounoudias, Ledin, Maki, Massion, Meyer, Nicolas Pinsault, Nicolas Vuillerme, Olivier Chenu, Peterka, Peterka, Picard, Priplata, Sampaio, Trulsson, Tyler, Vaillant, van Boven, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Vuillerme, Yohan Payan, Yuri Danilov   +43 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Physical, psychosocial and dual-career loads as risk factors for injuries and illnesses in elite handball players: a 45-week prospective cohort study

Frontiers in Sports and Active Living
IntroductionWhile training and competition load are well-documented risk factors for injury, the influence of dual-career loads, life stressors and overall load on both injury and illness remain less clear.
Kristina Drole, Armin Paravlic, Armin Paravlic, Kathrin Steffen, Kathrin Steffen, Mojca Doupona   +5 more
doaj   +1 more source

Tubulins in C. elegans [PDF]

, 2018
The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
core   +2 more sources

Sensory loss due to object formation

Vision Research, 2020
The precision to locate individual features in depth can often be improved by integrating information over space. However, this integration can sometimes be extremely detrimental, as for example in the case of the Westheimer-McKee phenomenon where features are grouped to form an object.
Pascal Mamassian, Marina Zannoli
openaire   +2 more sources

Assessment of Dementia in Individuals with Dual Sensory Loss: Application of a Tactile Test Battery

Dementia and Geriatric Cognitive Disorders Extra, 2018
Background/Aims: Individuals with dual sensory loss (DSL) are more likely to experience cognitive decline with age than individuals without sensory loss.
P. Bruhn, J. Dammeyer
semanticscholar   +1 more source