Results 111 to 120 of about 5,916,094 (333)

Bodily-tactile early intervention: a pilot study of the role of maternal touch and emotional availability in interactions between three children with visual impairment and additional disabilities and their mothers

Frontiers in Psychology
BackgroundChildren with visual impairment and additional disabilities (VIAD) have difficulty accessing the visual information related to their parents’ facial expressions and gestures.
Sini Peltokorpi, Sini Peltokorpi, Saara Salo, Anne Nafstad, Paul Hart, Zeynep Biringen, Minna Laakso   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sensory neuropathy and nociception in rodent models of Parkinson's disease

Disease Models & Mechanisms, 2019
Parkinson's disease (PD) often manifests with prodromal pain and sensory losses whose etiologies are not well understood. Multiple genetic and toxicity-based rodent models of PD partly recapitulate the histopathology and motor function deficits. Although
Lucie Valek, Georg Auburger, Irmgard Tegeder   +2 more
doaj   +1 more source

Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model [PDF]

, 2018
Background: The use of quantitative sensory testing (QST) in multicenter studies has been quite limited, due in part to lack of standardized procedures among centers. Aim: The aim of this study was to assess the application of the capsaicin pain model
Bushnell, M. Catherine, Chouchou, Florian, Ferland, Catherine E., Gandhi, Wiebke, Jackson, Philip L., Lavigne, Gilles, Ma, My-Linh, Marchand, Serge, Michon, Pierre-Emmanuel, Parent, Alexandre J., Rainville, Pierre, Schweinhardt, Petra, Villemure, Chantal, Ware, Mark A.   +13 more
core   +1 more source

Validity and Reliability of the Major Depression Inventory for Persons With Dual Sensory Loss

Innovation in aging, 2018
Background and Objectives Research has shown that dual sensory loss is a risk factor for depression in older adults. However, validated measures of depression for people with dual sensory loss are lacking.
H. B. Hovaldt, T. Nielsen, J. Dammeyer
semanticscholar   +1 more source

Age-Related Hearing Loss Is Dominated by Damage to Inner Ear Sensory Cells, Not the Cellular Battery That Powers Them

Journal of Neuroscience, 2020
Age-related hearing loss arises from irreversible damage in the inner ear, where sound is transduced into electrical signals. Prior human studies suggested that sensory-cell loss is rarely the cause; correspondingly, animal work has implicated the stria ...
Pei-zhe Wu, J. O'malley, V. De Gruttola, M. Liberman   +3 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

V144D Mutation of SPTLC1 Can Present with Both Painful and Painless Phenotypes in Hereditary Sensory and Autonomic Neuropathies Type I

Case Reports in Genetics, 2018
Hereditary sensory and autonomic neuropathy type I (HSAN I) is an autosomal dominant disease characterized by distal sensory loss, pain insensitivity, and autonomic disturbances.
Kwo Wei David Ho, Nivedita U. Jerath
doaj   +1 more source

Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors [PDF]

, 2017
The development of functional peripheral ganglia requires a balance of specification of both neuronal and glial components. In the developing dorsal root ganglia (DRGs), these compo- nents form from partially-restricted bipotent neuroglial precursors ...
Blader, Patrick, Busolin, Giorgia, Camargo Sosa, Karen, Colanesi, Sarah, Delfino Mach\uedn, Mariana, Kelsh, Robert N., Law, Edward W. P., Madelaine, Romain, Nikaido, Masataka, Tiso, Natascia, Toppo, Stefano   +10 more
core   +3 more sources

Interpersonal communication and psychological well-being among couples coping with sensory loss: The mediating role of perceived spouse support

Journal of Social and Personal Relationships, 2018
Couples who are willing to discuss sensory loss-related issues typically report better well-being, while couples who avoid such discussions tend to report poorer well-being.
Sofia Maria Hofsöe, Christine M. Lehane, W. Wittich, P. Hilpert, J. Dammeyer   +4 more
semanticscholar   +1 more source