Results 231 to 240 of about 397,035 (315)

3F1036 Eyeblink conditioning in DBA/2 mice depends on the ipsilateral cerebellar nuclei(3F Neuroscience & Sensory systems, Neuronal Circuit & Information processing, Behavior,The 49th Annual Meeting of the Biophysical Society of Japan)

, 2011
Yoichi Nakamura, Haruka Nishizawa, Shigenori Kawahara   +2 more
openalex   +2 more sources

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Connectivity and function are coupled across cognitive domains throughout the brain. [PDF]

Netw Neurosci
Hiersche KJ, Saygin ZM, Osher DE.
europepmc   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

When the brain listens to the kidney, is it TRP'n or what? [PDF]

J Physiol
Osborn JW, Evans LC, Banek CT, Vulchanova L, Dayton A.   +4 more
europepmc   +1 more source

3F1458 Chimeric Gα_<15_olf> improved response dynamics and odorant tuning specificity of odorant receptors expressing in HEK293 cells(3F Neuroscience & Sensory systems, Neuronal Circuit & Information processing,The 49th Annual Meeting of the Biophysical Society of Japan)

, 2011
Takaaki Sato, Hiroshi Hamana, Takashi Kawasaki, Junzo Hirono   +3 more
openalex   +2 more sources

Ecologically‐Valid Emotion Signatures Enhance Mood Disorder Diagnostics

Advanced Science, EarlyView.
This study identifies ecologically‐valid Divergent Emotional Functional Networks (DEFN), derived from dynamic functional connectivity during naturalistic movie watching. The DEFN reliably enhances diagnostic accuracy for mood disorders, including major depressive and bipolar disorders, demonstrating strong reproducibility across demographic factors and
Shuyue Xu, Linling Li, Ting Luo, Gan Huang, Li Zhang, Benjamin Becker, Zhen Liang   +6 more
wiley   +1 more source

Rhythmic Sensory Stimulation and Music-Based Interventions in Focal Epilepsy: Clinical Evidence, Mechanistic Rationale, and Digital Perspectives-A Narrative Review. [PDF]

J Clin Med
Narodova EA.
europepmc   +1 more source

Towards Human Sensory Augmentation: A Cognitive Neuroscience Framework for Evaluating Integration of New Signals within Perception, Brain Representations, and Subjective Experience [PDF]

Marko Nardini, Meike Scheller, Matthew Ramsay, Olaf Kristiansen, Chris Allen   +4 more
openalex   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source