Results 51 to 60 of about 397,035 (315)

A Network Analysis Approach to Detect and Differentiate Usher Syndrome Types Using miRNA Expression Profiles: A Pilot Study

BioMedInformatics
Background: Usher syndrome (USH) is a rare genetic disorder that affects both hearing and vision. It presents in three clinical types—USH1, USH2, and USH3—with varying onset, severity, and disease progression.
Rama Krishna Thelagathoti, Wesley A. Tom, Chao Jiang, Dinesh S. Chandel, Gary Krzyzanowski, Appolinaire Olou, Rohan M. Fernando   +6 more
doaj   +1 more source

On staying grounded and avoiding Quixotic dead ends [PDF]

, 2016
The 15 articles in this special issue on The Representation of Concepts illustrate the rich variety of theoretical positions and supporting research that characterize the area.
A Caramazza, A Martin, A Martin, A Paivio, AK Engel, AR Damasio, BZ Mahon, BZ Mahon, C Wong, CD Wilson-Mendenhall, D Caligiore, D Casasanto, D Kemmerer, D Kemmerer, D Legrand, DL Drane, DL Drane, E Akpinar, E Machery, E Rosch, EE Smith, EK Papies, F Huettig, F Pulvermüller, F Pulvermüller, F Pulvermüller, F Pulvermüller, F Schrodt, GL Murphy, J Henrich, J Santiago, JA Fodor, JA Hampton, JK O’Regan, JL McClelland, JR Binder, JR Searle, K Grill-Spector, K McRae, K McRae, K Meyer, K Patterson, L Connell, L Connell, L Doren Van, L Talmy, LAM Lebois, Lawrence W. Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, LW Barsalou, M Andrews, M Kiefer, M Kiefer, MA Lambon Ralph, MJ Farah, MJ Yates, MK Tanenhaus, ML Anderson, MM Louwerse, MM Louwerse, N Chomsky, PJ Schwanenflugel, RA Zwaan, RA Zwaan, RL Buckner, RM Braga, RW Langacker, S Harnad, SW Allen, TK Landauer, TT Rogers, V Walsh, WK Simmons, WK Simmons, WR Glaser, X Wang, ZW Pylyshyn   +86 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Machine Learning-Based Ensemble Feature Selection and Nested Cross-Validation for miRNA Biomarker Discovery in Usher Syndrome

Bioengineering
Usher syndrome (USH) is a rare genetic disorder affecting vision, hearing, and balance. Identifying reliable biomarkers is crucial for early diagnosis and understanding disease mechanisms.
Rama Krishna Thelagathoti, Dinesh S. Chandel, Wesley A. Tom, Chao Jiang, Gary Krzyzanowski, Appolinaire Olou, M. Rohan Fernando   +6 more
doaj   +1 more source

Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit

eLife, 2018
The lateral-line neuromast of the zebrafish displays a restricted, consistent pattern of innervation that facilitates the comparison of microcircuits across individuals, developmental stages, and genotypes.
Eliot Dow, Adrian Jacobo, Sajjad Hossain, Kimberly Siletti, A J Hudspeth   +4 more
doaj   +1 more source

I, NEURON: the neuron as the collective [PDF]

, 2017
Purpose – In the last half-century, individual sensory neurons have been bestowed with characteristics of the whole human being, such as behavior and its oft-presumed precursor, consciousness. This anthropomorphization is pervasive in the literature.
Nizami, Lance
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Inhibition of Thioredoxin Reductase Activity and Oxidation of Cellular Thiols by Antimicrobial Agent, 2-Bromo-2-nitro-1,3-propanediol, Causes Oxidative Stress and Cell Death in Cultured Noncancer and Cancer Cells

Biology
Background: The thioredoxin system (TrxS) is crucial for maintaining redox balance by regulating cellular thiol levels and is involved in various biological processes, including cancer progression.
Chao Jiang, Gary Krzyzanowski, Dinesh S. Chandel, Wesley A. Tom, Nirmalee Fernando, Appolinaire Olou, M. Rohan Fernando   +6 more
doaj   +1 more source

Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review

Audiology Research, 2016
An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL) patients. The purpose of our review was to: i) identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of ...
Nicola Quaranta, Vincenzo De Ceglie, Alessandra D’Elia   +2 more
doaj   +1 more source

The indirect corticopontine pathway relays perioral sensory signals to the cerebellum via the mesodiencephalic junction

iScience, 2023
Summary: In the cerebro–cerebellar loop, outputs from the cerebral cortex are thought to be transmitted via monosynaptic corticopontine gray (PG) pathways and subsequently relayed to the cerebellum.
Reika Kubo, Takayuki Yoshida, Kenji Yamaoka, Kouichi Hashimoto   +3 more
doaj   +1 more source