Results 31 to 40 of about 396,805 (256)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

I, NEURON: the neuron as the collective [PDF]

, 2017
Purpose – In the last half-century, individual sensory neurons have been bestowed with characteristics of the whole human being, such as behavior and its oft-presumed precursor, consciousness. This anthropomorphization is pervasive in the literature.
Nizami, Lance
core  

Neuronal circuitry for pain processing in the dorsal horn [PDF]

, 2010
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception.
A Dhaka, A Ribeiro-da-Silva, A Ribeiro-da-Silva, AF Keller, AG Brown, AH Watson, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AL Bailey, AM Taylor, Andrew J. Todd, AR Light, AW Hantman, AW Hantman, B Lynn, B Rexed, BA Graham, C Albuquerque, C Gauriau, C Gauriau, C Gauriau, C Torsney, CJ Woodbury, CJ Woodbury, CJ Woolf, D Andrew, D Lima, D Lima, D Lima, D Lima, D Schoffnegger, D Schoffnegger, D Uta, DI Hughes, DI Hughes, DI Hughes, DJ Cavanaugh, DJ Maxwell, DL Bennett, DS Bredt, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, ET Zhang, ET Zhang, G Kato, GG Nagy, GJ Bennett, GJ Michael, GT Whiteside, H Baba, H Bester, H Ikeda, H Ikeda, H Sakamoto, HJ Hu, HY Huang, I Decosterd, I Laing, J Sandkuhler, J Scholz, J Zheng, JA Coull, JA Esteban, JF Bernard, JH Hwang, JJ Azkue, JL Hylden, JM Castro-Lopes, K Abe, K Feil, K Noguchi, KA Moore, KM Al-Khater, KM Al-Khater, KS Al Ghamdi, L Almarestani, L Sivilotti, LE Lorenzo, M Antal, M Antal, M Gassner, M Larsson, M Malcangio, M Mori, M Naim, M Okamoto, M Randic, M Rethelyi, M Zoli, MB Plenderleith, MJ Eaton, MJ Perry, MJ Zylka, ML Nichols, MM Heinricher, MM Naim, MW Salter, NK Littlewood, P Boscan, P Brumovsky, P Shortland, PD Wall, PW Mantyh, PW Mantyh, Q Liu, R Burstein, R Ruscheweyh, R Ruscheweyh, RC Spike, RC Spike, RM Slugg, RP Seal, RR Ji, S Neumann, S Neumann, SA Prescott, SA Shehab, SF Santos, SH Kim, SN Lawson, SP Schneider, T Ibuki, T Kemp, T Kohno, T Yasaka, T Yasaka, TJ Grudt, TL Yaksh, TP Malan, VS Seybold, WD Snider, WD Willis, X Zhang, X Zhang, XH Yu, Y Lu, Y Lu, Y Lu, YG Tong, YQ Ding, Z Puskár, ZS Han   +159 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Machine Learning-Based Ensemble Feature Selection and Nested Cross-Validation for miRNA Biomarker Discovery in Usher Syndrome

Bioengineering
Usher syndrome (USH) is a rare genetic disorder affecting vision, hearing, and balance. Identifying reliable biomarkers is crucial for early diagnosis and understanding disease mechanisms.
Rama Krishna Thelagathoti, Dinesh S. Chandel, Wesley A. Tom, Chao Jiang, Gary Krzyzanowski, Appolinaire Olou, M. Rohan Fernando   +6 more
doaj   +1 more source

Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit

eLife, 2018
The lateral-line neuromast of the zebrafish displays a restricted, consistent pattern of innervation that facilitates the comparison of microcircuits across individuals, developmental stages, and genotypes.
Eliot Dow, Adrian Jacobo, Sajjad Hossain, Kimberly Siletti, A J Hudspeth   +4 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Prostaglandin E2 depolarises sensory axons in vitro in an ANO1 and Nav1.8 dependent manner

Scientific Reports
Prostaglandin E2 (PGE2) is a major contributor to inflammatory pain hyperalgesia, however, the extent to which it modulates the activity of nociceptive axons is incompletely understood.
Georgios Kimourtzis, Natasha Rangwani, Bethan J. Jenkins, Siddharth Jani, Peter A. McNaughton, Ramin Raouf   +5 more
doaj   +1 more source

Inhibition of Thioredoxin Reductase Activity and Oxidation of Cellular Thiols by Antimicrobial Agent, 2-Bromo-2-nitro-1,3-propanediol, Causes Oxidative Stress and Cell Death in Cultured Noncancer and Cancer Cells

Biology
Background: The thioredoxin system (TrxS) is crucial for maintaining redox balance by regulating cellular thiol levels and is involved in various biological processes, including cancer progression.
Chao Jiang, Gary Krzyzanowski, Dinesh S. Chandel, Wesley A. Tom, Nirmalee Fernando, Appolinaire Olou, M. Rohan Fernando   +6 more
doaj   +1 more source

Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review

Audiology Research, 2016
An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL) patients. The purpose of our review was to: i) identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of ...
Nicola Quaranta, Vincenzo De Ceglie, Alessandra D’Elia   +2 more
doaj   +1 more source