Results 111 to 120 of about 173,264 (311)

Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells [PDF]

, 2007
Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic ...
D’Souza, Vijay Kenneth
core  

Monoaminergic modulation of photoreception in ascidian:evidence for a proto-hypothalamo-retinal territory [PDF]

, 2012
The retina of craniates/vertebrates has been proposed to derive from a photoreceptor prosencephalic territory in ancestral chordates, but the evolutionary origin of the different cell types making the retina is disputed.
Kusakabe, Takehiro G, Takeo Horie, Brown, Euan R., Razy-Krajka, Florian, Brown, Euan R, Takehiro G Kusakabe, Sasakura, Yasunori, Jacques Callebert, Yasunori Sasakura, Kusakabe, Takehiro G., Jean-Stéphane Joly, Brown, Euan R; id_orcid, Philippe Vernier, Vernier, Philippe, Callebert, Jacques, Horie, Takeo, Florian Razy-Krajka, Joly, Jean-Stéphane, Euan R Brown   +18 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb

, 2007
The formation of precise stereotypic connections in sensory systems is critical for the ability to detect and process signals from the environment. In the olfactory system, olfactory sensory neurons (OSNs) project axons to spatially defined glomeruli ...
Cloutier, J-F, Cho, JH, Parnavelas, J, Andrews, W, Lépine, M   +4 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

P2X₃ Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP

, 2001
The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X₃ receptor knock-out (P2X₃ ⁻⁄⁻) and wild-type control (P2X₃ ⁺⁄⁺) mice.
Bodin, P, Cockayne, DA, Kasakov, L, Burnstock, G, Rong, W, Bardini, M, Ford, APDW, Vlaskovska, M   +7 more
core  

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Robinson, M, Rugiero, F, Colless, B, Drew, LJ, Brust, A, Heinzmann, S, Lewis, RJ, Wood, JN, Gale, JE, Cesare, P, Bowden, S   +11 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia [PDF]

, 2003
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately ...
Shima, D., Christiana Ruhrberg, Betsholtz, C, Jeltsch, M, Abramsson, A., Shima, D, Matthew Golding, Lundkvist, A, Lundkvist, A., Golding, M, David Shima, Ruhrberg, C, Christopher Mitchell, Mitchell, C, Betsholtz, C., Kari Alitalo, Gerhardt, H, Ruhrberg, C., Christer Betsholtz, Golding, M., Jeltsch, M., Holger Gerhardt, Abramsson, A, Alitalo, K, Andrea Lundkvist, Fruttiger, M., Gerhardt, H., Alitalo, K., Alexandra Abramsson, Mitchell, C., Fruttiger, M, Michael Jeltsch, Marcus Fruttiger   +32 more
core   +1 more source

IL-33/ST2 drives inflammatory pain via CCL2 signaling and activation of TRPV1 and TRPM8

Communications Biology
Innate immunity is the first line of host defense and contributes to pain. However, how innate immune system interacts with sensory neurons to govern pain remains poorly understood.
Linjie Wang, Jingyun Zhang, Shijuan Qiu, Ruizhen Huang, Yuge Wang, Yuting Wang, Mingyu Li, Qingqing Ye, Sibo Zhang, Zhenhua Qi, Lan Cao, Guohao Li, Yajie An, Denghui Xie, Wenli Mi, Huaqiao Wang, Tao Luo, Jingdun Xie, Junting Huang   +18 more
doaj   +1 more source