Results 101 to 110 of about 173,264 (311)

Histological characterization of the olfactory organ in schilbid catfish, Clupisoma garua (Hamilton, 1822)

International Journal of Aquatic Biology, 2018
Fishes have a good sense of smell and are able to ascertain odour with the help of a pair of olfactory organs connected to the olfactory lobes of the forebrain by means of olfactory tracts.
Saroj Kumar Ghosh
doaj   +1 more source

Subcellular localization of the P2X4 receptor in sensory hair cells of Wistar rat cochlea

Histochemistry and Cell Biology
Abstract Our sense of hearing starts in the inner ear organ, the cochlea, which contains two types of auditory hair cells for signal transduction. Earlier research showed that the complex cochlear physiology is regulated in part by purinergic signalling through activation of purine-mediated P2X, P2Y and adenosine receptors expressed ...
Huang, Ziyin, Ross, Jacqueline M., Lin, Shelly C. Y., Kumar, Prakansha N., Roy, Kevin, Vlajkovic, Srdjan M., Thorne, Peter R., Suzuki-Kerr, Haruna   +7 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists

, 2009
P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Topological reorganization of odor representations in the olfactory bulb. [PDF]

, 2007
Odors are initially represented in the olfactory bulb (OB) by patterns of sensory input across the array of glomeruli. Although activated glomeruli are often widely distributed, glomeruli responding to stimuli sharing molecular features tend to be ...
Friedrich, Rainer W., Benjamin Judkewitz, Rainer W Friedrich, Judkewitz, Benjamin, Yaksi, E., Yaksi, Emre, Friedrich, Rainer W, Judkewitz, B., Friedrich, R., Emre Yaksi   +9 more
core   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science
Adeno‐associated virus (AAV) vectors are a leading platform for gene therapy. Recently, AAV‐mediated gene therapy in the inner ear has progressed from laboratory use to clinical trials, but the lower transduction rates in outer hair cells (OHCs) in the ...
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
doaj   +1 more source

Ultrastructural and developmental anatomy of the peripheral olfactory organs of Dicentrarchus labrax inhabiting Egyptian Mediterranean water

Open Veterinary Journal
Background: Olfaction regulates animal behavior; hence its organs are seen early in fish development. Due to their aquatic lifestyle, fish employ olfaction to communicate chemical signals during gustation.
Sheren A. Al-Zahaby, Al-Ahmady S. Al-Zahaby, Radwa A. Mohamed, Eman H. Elsheikh   +3 more
doaj   +1 more source

Activation of TRPV4 regulates respiration through indirect activation of bronchopulmonary sensory neurons

Frontiers in Physiology, 2016
Transient receptor potential vanilloid receptor 4 (TRPV4) is a calcium-permeable non-selective cation channel implicated in numerous physiological and pathological functions.
Qihai (David) eGu, Charles R. Moss, Kristen L. Kettelhut, Carolyn A. Gilbert, Hongzhen eHu   +4 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source