Structural Features of an OR37 Glomerulus: A Comparative Study
Frontiers in Neuroanatomy, 2017 In the olfactory bulb (OB) a sophisticated neuronal network mediates the primary processing of sensory information and extensive investigations over the past decades have greatly improved our understanding of the morphology and neuronal organization of ...
Anna-Maria Maier +2 more
doaj +1 more source
Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear [PDF]
Molecular and Cellular Neuroscience, 2008 Nothing is known about the regulation of nicotinic acetylcholine receptors (nAChRs) in hair cells of the inner ear. MuSK, rapsyn and RIC-3 are accessory molecules associated with muscle and brain nAChR function. We demonstrate that these accessory molecules are expressed in the inner ear raising the possibility of a muscle-like mechanism for clustering
Abdullah A, Osman +6 more
openaire +2 more sources
Insulin-like peptides encode sensory information to regulate "C. elegans" development [PDF]
, 2010 The sensory system senses and conveys information about an animal’s complex environment to induce the optimal physiological and behavioral responses that are necessary for survival.
Cornils, Astrid
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis [PDF]
, 1994 Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and
Matt Cotten +5 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Macrophage Recruitment and Epithelial Repair Following Hair Cell Injury in the Mouse Utricle
Frontiers in Cellular Neuroscience, 2015 The sensory organs of the inner ear possess resident populations of macrophages, but the function of those cells is poorly understood. In many tissues, macrophages participate in the removal of cellular debris after injury and can also promote tissue ...
Tejbeer eKaur +3 more
doaj +1 more source
P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells [PDF]
, 2014 This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release.The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and ...
Campwala, H. +11 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Exploring developmental, functional, and evolutionary aspects of amphioxus sensory cells
International Journal of Biological Sciences, 2006 Amphioxus has neither elaborated brains nor definitive sensory organs, so that the two may have evolved in a mutually affecting manner and given rise to the forms seen in extant vertebrates.
Gouki Satoh
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