Results 61 to 70 of about 173,264 (311)

Colocalisation of insulin and IGF‐1 receptors in cultured rat sensory and sympathetic ganglion cells [PDF]

Journal of Anatomy, 1997
Peripheral sensory and autonomic neurons are known to possess insulin receptors. These have been considered to be of the peripheral type, i.e. similar to those of hepatic and fat cells rather than of the brain type which show dual specificity for both insulin and insulin‐like growth factor (IGF‐1). We have examined the localisation of insulin and IGF‐1
Karagiannis, Sophia N, King, Rosalind H. M., Thomas, P.K.   +2 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N., Samson, Andrew J., Alexander, Amy, Hothersall, J. Daniel   +5 more
core   +1 more source

The olfactory organ in the Gangetic catfish Ailia coila (Hamilton, 1822): structural and functional aspects

Journal of Fisheries, 2020
A study of the olfactory organ, with marked observation on cellular morphology of neuroepithelium was carried out in riverine catfish Ailia coila (Hamilton, 1822) using light and scanning electron microscopy.
Saroj Kumar Ghosh
doaj  

Neuronal soma–satellite glial cell interactions in sensory ganglia and the participation of purinergic receptors [PDF]

Neuron Glia Biology, 2010
It has been known for some time that the somata of neurons in sensory ganglia respond to electrical or chemical stimulation and release transmitters in a Ca2+-dependent manner. The function of the somatic release has not been well delineated. A unique characteristic of the ganglia is that each neuronal soma is tightly enwrapped by satellite glial cells
Yanping, Gu, Yong, Chen, Xiaofei, Zhang, Guang-Wen, Li, Congying, Wang, Li-Yen Mae, Huang   +5 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Scaling proprioceptor gene transcription by retrograde NT3 signaling [PDF]

, 2011
The assembly of neuronal circuits depends critically on the sequential activation of transcriptional programs in defined neuronal sub-populations. In the spinal cord, retrograde signaling interactions from the periphery have been shown to be essential ...
Lee, Jun
core   +1 more source

Histoarchitectural and surface ultrastructural analysis of the olfactory epithelium of Puntius ticto (Hamilton, 1822)

International Journal of Aquatic Biology, 2015
Organization of various cells lining the olfactory mucosa of Puntius ticto (Hamilton, 1822) were described by light as well as scanning electron microscopy.
Saroj Kumar Ghosh, Bappaditya Pan, Padmanabha Chakrabarti   +2 more
doaj  

Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression

Life Science Alliance
Crosstalk between bone metastatic cancer cells and sensory nerves has not yet been fully elucidated. We demonstrate the involvement of CGRP-expressing sensory nerves in bone metastatic progression and identify the CGRP/CRLR axis as a potential ...
Sun H Park, Shunsuke Tsuzuki, Kelly F Contino, Jenna Ollodart, Matthew R Eber, Yang Yu, Laiton R Steele, Hiroyuki Inaba, Yuko Kamata, Takahiro Kimura, Ilsa Coleman, Peter S Nelson, Enriqueta Muñoz-Islas, Juan Miguel Jiménez-Andrade, Thomas J Martin, Kimberly D Mackenzie, Jennifer R Stratton, Fang-Chi Hsu, Christopher M Peters, Yusuke Shiozawa   +19 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source