Results 51 to 60 of about 173,264 (311)

Mechanisms and consequences of reduced dendritic growth of cerebellar Purkinje cells [PDF]

, 2012
The cerebellum is a brain region crucial for coordination and motor learning. Being the principal output cell of the cerebellar cortex, Purkinje cell loss and degeneration play an important role in many cerebellar diseases.
Gugger, Olivia S.
core   +1 more source

NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons

Journal of Neuroinflammation
Nociceptors are primary afferent neurons that sense noxious stimuli. They can be activated by tissue injury as well as the accompanying local immune response.
Shuaiwei Wang, Allison M. Barry, Yoon Kyung Lee, Naomi Young, Sang Wook Shim, Xinying Wang, Hyeongcheol Kim, Laura Stirling-Barros, Rafael González-Cano, Michael Costigan, Georgios Baskozos, Simon Rinaldi, David LH Bennett, Seog Bae Oh, Alexander J. Davies   +14 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

TLR7 is expressed by support cells, but not sensory neurons, in ganglia

Journal of Neuroinflammation, 2021
Background Toll-like receptor 7 (TLR7) is an innate immune receptor that detects viral single-stranded RNA and triggers the production of proinflammatory cytokines and type 1 interferons in immune cells. TLR7 agonists also modulate sensory nerve function
Becky J. Proskocil, Karol Wai, Katherine M. Lebold, Mason A. Norgard, Katherine A. Michaelis, Ubaldo De La Torre, Madeline Cook, Daniel L. Marks, Allison D. Fryer, David B. Jacoby, Matthew G. Drake   +10 more
doaj   +1 more source

Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice

eLife, 2017
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates. However, there is no definitive evidence that this process occurs in mammals.
Stephanie A Bucks, Brandon C Cox, Brittany A Vlosich, James P Manning, Tot B Nguyen, Jennifer S Stone   +5 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Polarization and migration in the zebrafish posterior lateral line system. [PDF]

PLoS Computational Biology, 2017
Collective cell migration plays an important role in development. Here, we study the posterior lateral line primordium (PLLP) a group of about 100 cells, destined to form sensory structures, that migrates from head to tail in the zebrafish embryo.
Hildur Knutsdottir, Cole Zmurchok, Dhananjay Bhaskar, Eirikur Palsson, Damian Dalle Nogare, Ajay B Chitnis, Leah Edelstein-Keshet   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural characterization of the olfactory epithelium of freshwater olive barb, Puntius sarana (Hamilton, 1822)

International Journal of Aquatic Biology, 2014
The cellular organization of the olfactory epithelium of Puntius sarana (Hamilton, 1822) was explored by means of optical and scanning electron microscopy.
Saroj Kumar Ghosh, Padmanabha Chakrabarti   +1 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source