Results 31 to 40 of about 5,832,680 (299)

Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling

eLife, 2015
The sensory and supporting cells (SCs) of the organ of Corti are derived from a limited number of progenitors. The mechanisms that regulate the number of sensory progenitors are not known.
Sung-Ho Huh, Mark E Warchol, David M Ornitz   +2 more
doaj   +1 more source

Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3

npj Breast Cancer, 2022
In breast cancer, nerve presence has been correlated with more invasive disease and worse prognosis, yet the mechanisms by which different types of peripheral nerves drive tumor progression remain poorly understood.
Thanh T. Le, Samantha L. Payne, Maia N. Buckwald, Lily A. Hayes, Savannah R. Parker, Christopher B. Burge, Madeleine J. Oudin   +6 more
doaj   +1 more source

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells [PDF]

Open Biology, 2012
Summary Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice caused no behavioural phenotype, although loss of TRPC3 caused a shift of rapidly ...
Kathryn Quick, Jing Zhao, Niels Eijkelkamp, John E. Linley, Francois Rugiero, James J. Cox, Ramin Raouf, Martine Gringhuis, Jane E. Sexton, Joel Abramowitz, Ruth Taylor, Andy Forge, Jonathan Ashmore, Nerissa Kirkwood, Corné J. Kros, Guy P. Richardson, Marc Freichel, Veit Flockerzi, Lutz Birnbaumer, John N. Wood   +19 more
doaj   +1 more source

Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization

Molecular Pain, 2018
Background We have previously reported that histamine-induced pruritus was attenuated in toll-like receptor 4 (TLR4) knockout mice due to decreased transient receptor potential V1 (TRPV1) sensitivity.
Hyunjung Min, Woo-Hyun Cho, Hyunkyoung Lee, Boomin Choi, Yoon-Jung Kim, Han Kyu Lee, Yeonhee Joo, Sung Jun Jung, Se-Young Choi, Soojin Lee, Sung Joong Lee   +10 more
doaj   +1 more source

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Berger, Eric G, Mechtler, Karl, Rusconi, Sandro, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt, Clausen, Erik, Dinter, André, Thurnher, Martin, Berger, Erik G., Clausen, Henrik, Birnstiel, Max L   +12 more
core   +1 more source

Formation and Long-Term Culture of hiPSC-Derived Sensory Nerve Organoids Using Microfluidic Devices

Bioengineering
Although methods for generating human induced pluripotent stem cell (hiPSC)-derived motor nerve organoids are well established, those for sensory nerve organoids are not.
Takuma Ogawa, Souichi Yamada, Shuetsu Fukushi, Yuya Imai, Jiro Kawada, Kazutaka Ikeda, Seii Ohka, Shohei Kaneda   +7 more
doaj   +1 more source

Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron

eLife, 2014
Changes in temperature affect biochemical reaction rates and, consequently, neural processing. The nervous systems of poikilothermic animals must have evolved mechanisms enabling them to retain their functionality under varying temperatures. Auditory receptor neurons of grasshoppers respond to sound in a surprisingly temperature-compensated manner ...
Roemschied, Frederic A, Eberhard, Monika JB, Schleimer, Jan-Hendrik, Ronacher, Bernhard, Schreiber, Susanne   +4 more
openaire   +5 more sources

Gustatory sensory cells express a receptor responsive to protein breakdown products (GPR92) [PDF]

Histochemistry and Cell Biology, 2013
The ingestion of dietary protein is of vital importance for the maintenance of fundamental physiological processes. The taste modality umami, with its prototype stimulus, glutamate, is considered to signal the protein content of food. Umami was thought to be mediated by the heterodimeric amino acid receptor, T1R1 + T1R3.
Désirée, Haid, Patricia, Widmayer, Anja, Voigt, Nirupa, Chaudhari, Ulrich, Boehm, Heinz, Breer   +5 more
openaire   +2 more sources

Regulation of boundary cap neural crest stem cell differentiation after transplantation [PDF]

, 2009
Success of cell replacement therapies for neurological disorders will depend largely on the optimization of strategies to enhance viability and control the developmental fate of stem cells after transplantation.
Hjerling-Leffler, J, Aldskogius, Hakan, Wegner, M, Hjerling-Leffler, Jens, Kozlova, Elena N, Medvinsky, Alexander, Berens, C, Aldskogius, H, Kozlova, EN, Berens, Christian, Kanaykina, Nadezda, Sandelin, Martin, Schreiner, S, Wegner, Michael, Kanaykina, N, Sandelin, M, Liakhovitskaia, A, Medvinsky, A, Liakhovitskaia, Anna, Schreiner, Silke   +19 more
core   +1 more source

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival

Frontiers in Cellular Neuroscience, 2019
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin, Peter R. Thorne, Gary D. Housley, Srdjan M. Vlajkovic   +3 more
doaj   +1 more source