Results 31 to 40 of about 173,264 (311)

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells [PDF]

Open Biology, 2012
Summary Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice caused no behavioural phenotype, although loss of TRPC3 caused a shift of rapidly ...
Kathryn Quick, Jing Zhao, Niels Eijkelkamp, John E. Linley, Francois Rugiero, James J. Cox, Ramin Raouf, Martine Gringhuis, Jane E. Sexton, Joel Abramowitz, Ruth Taylor, Andy Forge, Jonathan Ashmore, Nerissa Kirkwood, Corné J. Kros, Guy P. Richardson, Marc Freichel, Veit Flockerzi, Lutz Birnbaumer, John N. Wood   +19 more
doaj   +1 more source

The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes

, 2005
The boundary cap (BC) is a transient neural crest-derived group of cells located at the dorsal root entry zone (DREZ) that have been shown to differentiate into sensory neurons and glia in vivo.
Hjerling-Leffler, J, Enerbäck, Sven, Hjerling-Leffler, Jens, Cederberg, A, Koltzenburg, M, Enerback, S, Cederberg, Anna,, Marmigère, Frédéric, Heglind, Mikael,, Enerbäck, Sven,, Koltzenburg, Martin, Ernfors, Patrik, Heglind, M, Ernfors, P, Heglind, Mikael, Cederberg, Anna, Marmigere, F   +16 more
core   +1 more source

Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization

Molecular Pain, 2018
Background We have previously reported that histamine-induced pruritus was attenuated in toll-like receptor 4 (TLR4) knockout mice due to decreased transient receptor potential V1 (TRPV1) sensitivity.
Hyunjung Min, Woo-Hyun Cho, Hyunkyoung Lee, Boomin Choi, Yoon-Jung Kim, Han Kyu Lee, Yeonhee Joo, Sung Jun Jung, Se-Young Choi, Soojin Lee, Sung Joong Lee   +10 more
doaj   +1 more source

Gustatory sensory cells express a receptor responsive to protein breakdown products (GPR92) [PDF]

Histochemistry and Cell Biology, 2013
The ingestion of dietary protein is of vital importance for the maintenance of fundamental physiological processes. The taste modality umami, with its prototype stimulus, glutamate, is considered to signal the protein content of food. Umami was thought to be mediated by the heterodimeric amino acid receptor, T1R1 + T1R3.
Désirée, Haid, Patricia, Widmayer, Anja, Voigt, Nirupa, Chaudhari, Ulrich, Boehm, Heinz, Breer   +5 more
openaire   +2 more sources

Formation and Long-Term Culture of hiPSC-Derived Sensory Nerve Organoids Using Microfluidic Devices

Bioengineering
Although methods for generating human induced pluripotent stem cell (hiPSC)-derived motor nerve organoids are well established, those for sensory nerve organoids are not.
Takuma Ogawa, Souichi Yamada, Shuetsu Fukushi, Yuya Imai, Jiro Kawada, Kazutaka Ikeda, Seii Ohka, Shohei Kaneda   +7 more
doaj   +1 more source

The odontoblast as a sensory receptor cell? The expression of TRPV1 (VR-1) channels

Archives of Histology and Cytology, 2005
Previous reports have shown the expression of several mechanosensitive ionic channels on the plasma membrane in odontoblasts, which are the cells responsible for dentin formation. The membrane characteristics of odontoblasts imply that they could play critical roles in the mechano-transduction of fluid displacement within dentinal tubules into the ...
Okumura, R, Shima, K, Muramatsu, T, Nakagawa, K, Shimono, M, Suzuki, T, Magloire, H, Shibukawa, Y   +7 more
openaire   +4 more sources

Emergence of functional sensory subtypes as defined by transient receptor potential channel expression

, 2007
The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
Hjerling-Leffler, J, Ernfors, P, Ernfors, P,, Koltzenburg, M, AlQatari, M   +4 more
core   +1 more source

GABA increases electrical excitability in a subset of human unmyelinated peripheral axons [PDF]

, 2010
A proportion of small diameter primary sensory neurones innervating human skin are chemosensitive. They respond in a receptor dependent manner to chemical mediators of inflammation as well as naturally occurring algogens, thermogens and pruritogens.
Sittl Ruth, Sittl, Ruth, Fleckenstein, Johannes, Richard W Carr, Ruth Sittl, Carr, Richard W, Peter Grafe, Grafe, Peter, Johannes Fleckenstein, Carr Richard W., Fleckenstein Johannes, Grafe Peter   +11 more
core   +1 more source

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival

Frontiers in Cellular Neuroscience, 2019
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin, Peter R. Thorne, Gary D. Housley, Srdjan M. Vlajkovic   +3 more
doaj   +1 more source

Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons. [PDF]

PLoS ONE, 2013
Developing sensory neurons require neurotrophic support for survival, neurite outgrowth and myelination. The low-density lipoprotein receptor-related protein-1 (LRP1) transactivates Trk receptors and thereby functions as a putative neurotrophin.
Kazuyo Yamauchi, Tomonori Yamauchi, Elisabetta Mantuano, Kenichi Murakami, Kenneth Henry, Kazuhisa Takahashi, Wendy Marie Campana   +6 more
doaj   +1 more source