Results 71 to 80 of about 5,832,680 (299)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression

Life Science Alliance
Crosstalk between bone metastatic cancer cells and sensory nerves has not yet been fully elucidated. We demonstrate the involvement of CGRP-expressing sensory nerves in bone metastatic progression and identify the CGRP/CRLR axis as a potential ...
Sun H Park, Shunsuke Tsuzuki, Kelly F Contino, Jenna Ollodart, Matthew R Eber, Yang Yu, Laiton R Steele, Hiroyuki Inaba, Yuko Kamata, Takahiro Kimura, Ilsa Coleman, Peter S Nelson, Enriqueta Muñoz-Islas, Juan Miguel Jiménez-Andrade, Thomas J Martin, Kimberly D Mackenzie, Jennifer R Stratton, Fang-Chi Hsu, Christopher M Peters, Yusuke Shiozawa   +19 more
doaj   +1 more source

Receptor-interacting protein kinases modulate noise-induced sensory hair cell death [PDF]

Cell Death & Disease, 2014
Receptor-interacting protein (RIP) kinases promote the induction of necrotic cell death pathways. Here we investigated signaling pathways in outer hair cells (OHCs) of adult male CBA/J mice exposed to noise that causes permanent threshold shifts, with a particular focus on RIP kinase-regulated necroptosis.
Zheng, H-W, Chen, J, Sha, S-H
openaire   +2 more sources

Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb [PDF]

, 2007
The formation of precise stereotypic connections in sensory systems is critical for the ability to detect and process signals from the environment. In the olfactory system, olfactory sensory neurons (OSNs) project axons to spatially defined glomeruli ...
Cloutier, J-F, Cho, JH, Parnavelas, J, Andrews, W, Lépine, M   +4 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Morphological evaluation of Merkel cells and small lamellated sensory receptors in the equine foot

American Journal of Veterinary Research, 2017
Abstract OBJECTIVE To examine the equine foot for the presence of sensory receptors including Merkel cells and small lamellated Pacinian-like corpuscles (SLPCs). SAMPLE Forefeet obtained from 7 horses following euthanasia for reasons other than foot disease.
Robert M, Bowker, Lisa S, Lancaster, Diane A, Isbell   +2 more
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Transcription Factors Expressed in Mouse Cochlear Inner and Outer Hair Cells.

PLoS ONE, 2016
Regulation of gene expression is essential to determining the functional complexity and morphological diversity seen among different cells. Transcriptional regulation is a crucial step in gene expression regulation because the genetic information is ...
Yi Li, Huizhan Liu, Cody L Barta, Paul D Judge, Lidong Zhao, Weiping J Zhang, Shusheng Gong, Kirk W Beisel, David Z Z He   +8 more
doaj   +1 more source

Neuronal soma–satellite glial cell interactions in sensory ganglia and the participation of purinergic receptors [PDF]

Neuron Glia Biology, 2010
It has been known for some time that the somata of neurons in sensory ganglia respond to electrical or chemical stimulation and release transmitters in a Ca2+-dependent manner. The function of the somatic release has not been well delineated. A unique characteristic of the ganglia is that each neuronal soma is tightly enwrapped by satellite glial cells
Yanping, Gu, Yong, Chen, Xiaofei, Zhang, Guang-Wen, Li, Congying, Wang, Li-Yen Mae, Huang   +5 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source