Results 121 to 130 of about 334,209 (303)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

SYSTEMS AND METHODS FOR CONTROLLING LEVELS OF PERCEIVED INTENSITY OF A SENSORY STIMULUS

, 2017
Dustin J. Tyler, Emily Lauren Graczyk, Sliman Julien Bensmaia, Benoit Pierre Delhaye, Phillipp Saal Hannes   +4 more
openalex   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Multisensory Approach in Education

Педагогически форум
Children learn by receiving information through their senses. Multisensory learning involves the use of the visual, auditory, kinetic and tactile channels to support the development of learning and mental processes.
Zhana Georgieva
doaj   +1 more source

Insufficiencies in sensory systems reweighting is associated with walking impairment severity in chronic stroke: an observational cohort study. [PDF]

Front Neurol, 2023
Awosika OO, Garver A, Drury C, Sucharew HJ, Boyne P, Schwab SM, Wasik E, Earnest M, Dunning K, Bhattacharya A, Khatri P, Kissela BM.   +11 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Sensory Systems and Transcriptional Regulation in Escherichia coli. [PDF]

Front Bioeng Biotechnol, 2022
Femerling G, Gama-Castro S, Lara P, Ledezma-Tejeida D, Tierrafría VH, Muñiz-Rascado L, Bonavides-Martínez C, Collado-Vides J.   +7 more
europepmc   +1 more source

A Protein Sensory System Comprising a Fluorescent Conjugated Polyelectrolyte and DNA Aptamer

, 2015
Jihye Son, Choongho Kim, Taek Seung Lee
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source