Results 71 to 80 of about 10,157,286 (286)

Seminar: sensory stories retold

open access: yes
The Sensory Stories Retold seminar showcased the first year of the Sensory Objects project, which was based at Speke Hall, a National Trust house in Liverpool.
Minnion, Andy   +3 more
core   +5 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Hearing abilities and acoustic signalization of the bottlenose dolphin Tursiops Truncatus with early hearing loss

open access: yesFrontiers in Marine Science
Common bottlenose dolphins (Tursiops truncatus) are among non-human mammals that possess the ability for vocal production learning, which strongly depends on learning from conspecifics. The hearing sensitivity and acoustic signals of a 4-year-old captive-
Evgeniya Sysueva   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The Ca2+-activated K+ current of human sperm is mediated by Slo3

open access: yeseLife, 2014
Sperm are equipped with a unique set of ion channels that orchestrate fertilization. In mouse sperm, the principal K+ current (IKSper) is carried by the Slo3 channel, which sets the membrane potential (Vm) in a strongly pHi-dependent manner.
Christoph Brenker   +10 more
doaj   +1 more source

Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease

open access: yeseLife, 2020
Neuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind.
Henri Leinonen   +5 more
doaj   +1 more source

Sensory Texture and Fundamental Rheology of Agar and Agarose Gels

open access: yes, 2006
Texture properties of foods are an important component of food quality perception and acceptability. In order to design specific textures with predictable sensory attributes, a molecular understanding of food structures and their corresponding texture is
Barrangou, Lisa
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Trends in robot-assisted and virtual reality-assisted neuromuscular therapy: a systematic review of health-related multiplayer games

open access: yesJournal of NeuroEngineering and Rehabilitation, 2018
Background Multiplayer games have emerged as a promising approach to increase the motivation of patients involved in rehabilitation therapy. In this systematic review, we evaluated recent publications in health-related multiplayer games that involved ...
Kilian Baur   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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