Results 51 to 60 of about 20,649 (261)

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

FOREST AREA DERIVATION FROM SENTINEL-1 DATA [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2016
The recently launched Sentinel-1A provides the high resolution Synthetic Aperture Radar (SAR) data with very high temporal coverage over large parts of European continent.
A. Dostálová, M. Hollaus, M. Milenković, W. Wagner   +3 more
doaj   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Wuhan Surface Subsidence Analysis in 2015–2016 Based on Sentinel-1A Data by SBAS-InSAR

Remote Sensing, 2017
The Terrain Observation with Progressive Scans (TOPS) acquisition mode of Sentinel-1A provides a wide coverage per acquisition and features a repeat cycle of 12 days, making this acquisition mode attractive for surface subsidence monitoring.
Lv Zhou, Jiming Guo, Jiyuan Hu, Jiangwei Li, Yongfeng Xu, Yuanjin Pan, Miao Shi   +6 more
doaj   +1 more source

INTEGRATED SHORELINE EXTRACTION APPROACH WITH USE OF RASAT MS AND SENTINEL-1A SAR IMAGES [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
Shorelines are complex ecosystems and highly important socio-economic environments. They may change rapidly due to both natural and human-induced effects.
N. Demir, S. Oy, F. Erdem, D. Z. Şeker, B. Bayram   +4 more
doaj   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Utilization of PS-InSAR for Analyzing Land Subsidence in the Bandung Basin, Indonesia using Sentinel-1A Data

Jurnal Elkomika
ABSTRAK Cekungan Bandung, yang terletak di Provinsi Jawa Barat, Indonesia, rentan terhadap penurunan muka tanah. Penelitian ini menganalisis laju penurunan muka tanah di Cekungan Bandung selama tahun 2019 menggunakan metode PS-InSAR yang diterapkan ...
DEWI KANIA SARI, HENRI KUNCORO, RIAN NURTYAWAN   +2 more
doaj   +1 more source

InSAR-based indentification and spatial distribution analysis of active landslides in the Western Sichuan Plateau

Dizhi lixue xuebao, 2023
The Chengdu plain westward to the Songpan-Ganzi fold belt is a transition zone from basin to plateau. The region has huge undulation and fall, strange and steep terrain, severe river undercutting and erosion, frequent tectonic activities, and strong ...
LIU Xinghong, YAO Xin, YANG Bo, TANG Wenkun, ZHOU Zhenkai   +4 more
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source