Results 81 to 90 of about 4,684,027 (296)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Separate States

Journal of Visual Art Practice, 2023
This piece separates various parts of a series of readymade archival image descriptions and relocates them into new, categorised spaces. With separation and relocation, the narrative of events apparent in the descriptions and in the album of photographs they define is de-emphasised (although the narrative can, in part, be re-built, due to archival ...
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Simultaneous voltage-gated control of ion and water transport in Zr4-Ti3C2Tx nanochannel membranes

Nature Communications
Controlling water and ion transport across nanoconfined channels is essential for natural biological processes and crucial for breakthroughs in diverse scientific and technological fields.
Yanlin Zhang, Lei Lei, Jin Wang, Shangzhen Li, Yanzheng Liu, Yuqing Sun, Tongxin Liao, Rong Chen, Cong Wang, Kexin Wang, Fulai Luo, Ke Zhou, Bohao Lv, Lei Wang   +13 more
doaj   +1 more source

Figure-Ground Separation [PDF]

, 1994
Air Force Office of Scientific Research (F49620-92-J-0499); Advanced Research Projects Agency (ONR N00014-92-J-4015); Office of Naval Research (N00014-91-J ...
Grossberg, Stephen
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Phase separation and large deviations of lattice active matter

, 2017
Off-lattice active Brownian particles form clusters and undergo phase separation even in the absence of attractions or velocity-alignment mechanisms. Arguments that explain this phenomenon appeal only to the ability of particles to move persistently in a
Klymko, Katherine, Mandal, Dibyendu, Whitelam, Stephen   +2 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Modern Misconceptions on the Wall of Separation: An Analysis on the Influence and Misinterpretation of Jefferson’s Separation of Church and State [PDF]

, 2019
The symbolic concept of separation between church and state defines the relationship between government and religion. While Jefferson did not author the phrase, the third President of the United States promoted the philosophy of a wall of separation ...
Swope, Marissa
core   +2 more sources