Results 151 to 160 of about 458,697 (317)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Does high hydrophilic complexing agent concentration enhance separation factors in “push-pull” extraction systems?

General equations describing the separation factors applicable to “push–pull” extraction systems using neutral and acidic organophosphorus extractants were derived.
Zhao, Qi, Shih, Kaimin
core   +1 more source

Dehydration Performance of a Compact Electrostatic Separator for High Water-Cut Oil Emulsions

Shiyou jixie
Compact electric field demulsification separation technology is an effective solution to the challenges of large footprint and low operational efficiency associated with conventional crude oil dehydration equipment on offshore platforms.
Shi Yi, Shen Shuaishuai, Chen Jiaqing, Zheng Qingwei, Dong Jianyu, Wang Yuhao, Wu Bi   +6 more
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Development of Coalescence Coupled Hydrocyclone Assembly

Shiyou jixie, 2018
The oil removing effect of hydrocyclone is not only related to the structure size of cyclone pipe, but also to its pretreatment and the type of lifting pump.
Zhao Chongwei, Wang Chungang, Gong Jian, Liu Kaiwen, Cao Yuan   +4 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effects of different quantities of antibody conjugated with magnetic nanoparticles on cell separation efficiency. [PDF]

Heliyon, 2020
Haghighi AH, Khorasani MT, Faghih Z, Farjadian F.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Extraction of Rubidium and Cesium Ions by Adsorption–Flotation Separation in Titanosilicate-Hexadecyltrimethylammonium Bromide System

This study centers on the adsorption–flotation coupling extraction of rubidium (Rb+) and cesium (Cs+) within a titanium silicate (CTS)–cetyltrimethylammonium bromide (CTAB) system, systematically investigating the impacts of pH, aeration rate,
Dezhen Fang, Xiushen Ye, Yanping Wang, Haining Liu, Wenjie Han   +4 more
core   +1 more source