Results 61 to 70 of about 590,817 (334)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Political and Administrative Dichotomy in South Africa: The Principle of Separation of Powers at Local Government Level

Acta Universitatis Danubius: Administratio, 2020
The study of political and administrative dichotomy in the discipline of public administration has always been about the differences that occur within the framework of government institutions.
Sihle Ashia Vilakazi, Toyin Cotties Adetiba   +1 more
doaj  

Separaţia puterilor in stat: teoria clasică nu mai exprimă realitatea politică [PDF]

Revista Institutului Naţional de Justiţie, 2016
The theory of separation of the three powers in the state has been for over two centuries. In different countries it has evolved in a different way. The author mentions the fact that even in the framework of the same state the separation of powers can ...
Moldoveanu Bianca
doaj  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Critical Reassessment of the Concept of Separation of Powers in the Legal-Political Thought of Imam Khomeini [PDF]

دانش حقوق عمومی
The idea of Islamic governance as proposed by Imam Khomeini fundamentally aligns with the practical wisdom of tradition; however, it is effectively shaped by concepts developed within the context of classical political thought and modern state theory ...
Zahra Sarempour, Mohamad Javaheri Tehrani   +1 more
doaj   +1 more source

New Hampshire’s Claremont Case and the Separation of Powers [PDF]

, 2006
[Excerpt] Court decisions involving the adequacy of public education raise some obvious separation of powers problems. These include the institutional competency of courts to determine what level of education is adequate and how much funding is ...
Mosca, Edward C.
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Congressional Devolution of Immigration Policymaking: A Separation of Powers Critique [PDF]

, 2007
For roughly a decade, federal legislation has devolved to the states some of Congress\u27s authority to adopt immigration policies that discriminate against permanent resident aliens.
Hartley, Roger C.
core   +2 more sources

„Stará“ a „nová“ dělba moci: nový pohled na starý koncept

Časopis pro Právní Vědu a Praxi, 2018
Recenze publikací MÖLLERS, Christoph. The Three Branches. A Comparative Model of Separation of Powers. Oxford: Oxford University Press, 2013, 263 s. CAROLAN, Eoin. The New Separation of Powers. A Theory for Modern State. Oxford: Oxford University Press,
Adam Blisa
doaj