Results 191 to 200 of about 573,828 (318)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effects of Operational Parameters on Mg²⁺/Li⁺ Separation Performance in Electrodialysis System. [PDF]

Membranes (Basel)
Zhao Z, Yang J, Kong D, Peng Y, Jin D.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effect of VTMS-Modified TiO₂ Nanoparticles on CO₂ Separation Performance of Polysulfone-Based Mixed Matrix Membranes. [PDF]

Membranes (Basel)
Alsaady M, Usman MF, Mannan HA, Ali MAB, Abdulrahman A, Ahmed A, Ilyas SU.   +6 more
europepmc   +1 more source

Simple and enlarged separation portfolios. On their Use when Arbitraging and Synthesizing Securities. [PDF]

This paper seeks to provide a framework for separation portfolios when they are used not only as synthetics of a matching security but also as building blocks of arbitrage portfolios, in a background provided by the CAPM world.
Rodolfo Apreda
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Charged Superhydrophilic Polyelectrolyte/TiO₂ Nanofiltration Membrane for Self-Cleaning and Separation Performance. [PDF]

Membranes (Basel)
Gu W, Han L, Li Y, Wang J, Yan H, Qin Z, Guo H.   +6 more
europepmc   +1 more source

Developing Mixed Matrix Membranes with Good CO₂ Separation Performance Based on PEG-Modified UiO-66 MOF and 6FDA-Durene Polyimide. [PDF]

Polymers (Basel), 2023
Adot Veetil K, Husna A, Kabir MH, Jeong I, Choi O, Hossain I, Kim TH.   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Double-Crosslinked H-PAN/MoS₂/PEI Composite Nanofiltration Membrane for Ethanol Systems: Fabrication and Dye Separation Performance. [PDF]

Membranes (Basel)
Zhang Y, Liu C, Zhu L, Zhou X, Wang M, Shen Y.   +5 more
europepmc   +1 more source