Results 101 to 110 of about 1,164,827 (340)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Confidence sets in sparse regression
, 2013 The problem of constructing confidence sets in the high-dimensional linear model with $n$ response variables and $p$ parameters, possibly $p\ge n$, is considered. Full honest adaptive inference is possible if the rate of sparse estimation does not exceed
Nickl, Richard, van de Geer, Sara
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Effective Monoaural Speech Separation through Convolutional Top-Down Multi-View Network
Future InternetSpeech separation, sometimes known as the “cocktail party problem”, is the process of separating individual speech signals from an audio mixture that includes ambient noises and several speakers.
Aye Nyein Aung +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Detection of the large scale alignment of massive galaxies at z~0.6
, 2013 We report on the detection of the alignment between galaxies and large-scale structure at z~0.6 based on the CMASS galaxy sample from the Baryon Oscillation Spectroscopy Survey data release 9.
Faltenbacher, A. +3 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Epidemiology of Separation Anxiety Disorder in Isfahan Primary School Male Students
مجله اپیدمیولوژی ایران, 2012 Background & Objectives: One of the most common anxiety disorders in children is separation anxiety disorder (SAD). The purpose of the present study was to investigate the epidemiology of separation anxiety disorder in Isfahan primary school male student.
A Nassi +4 more
doaj
Algorithm for Reducing the Number of Forwarding Rules Created by SDN Applications
Моделирование и анализ информационных систем, 2019 Software-Defined Networking (SDN) is a network architecture that introduces a physical separation of data-plane from control-plane. It implements a new way of analyzing network statistics through counters installed on forwarding rules.
Ivan S. Petrov
doaj +1 more source
Universal statistics of non-linear energy transfer in turbulent models
, 1996 A class of shell models for turbulent energy transfer at varying the inter-shell separation, $\lambda$, is investigated. Intermittent corrections in the continuous limit of infinitely close shells ($\lambda \rightarrow 1$) have been measured.
B. Dubrulle +24 more
core +1 more source