Results 21 to 30 of about 65,174 (128)

Transaminase and Norcoclaurine Synthase One‐Pot Cascades Towards (1S)‐Tetrahydroisoquinolines

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
A TAm‐NCS cascade towards THIQs has been established, starting from amines with the in situ production of aldehydes. The cascade was used with a variety of nonfunctionalized and functionalized amines, and reaction conditions modified to enhance formation of the desired cross‐products.
Jianxiong Zhao, Yeke Ni, Yu Wang, John M. Ward, Jack W. E. Jeffries, Helen C. Hailes   +5 more
wiley   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, Volume 13, Issue 16, 18 March 2026.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

An Ad5‐Based COVID‐19 Vaccine Encoding SARS‐CoV‐2 Spike Glycoprotein Induces Measurable Antibody and Cytokine Responses in Mice

Biotechnology Journal, Volume 21, Issue 3, March 2026.
Graphical Abstract and Lay Summary A recombinant adenovirus type 5–based vaccine encoding the full‐length SARS‐CoV‐2 Spike glycoprotein (Ad5Spike) was evaluated for its ability to induce cellular and humoral immune responses in BALB/c mice. Immunization with Ad5Spike resulted in the generation of antigen‐specific cellular immunity, characterized by ...
Fulya Erendor, Fatih Uzer, Salih Sanlioglu   +2 more
wiley   +1 more source

Isolation, RP‐UHPLC‐ESI‐LIT‐Orbitrap‐MS/MS‐Based Metabolic Profiling and Anticandidal Activity of the Root and Leaf Secondary Metabolites of Monotes Kerstingii Gilg (Dipterocarpaceae)

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
This paper describes the isolation and antifungal activity of secondary metabolites from the leaves and roots of Monotes kerstingii. The distribution of these metabolites in the roots and leaves was achieved through comprehensive RP‐UHPLC‐Orbitrap‐MS and MS/MS analysis.
Sorelle Kache Fotsing, Dominique Ngnintedo, Yanick Kevin Dongmo Melogmo, Alena Soboleva, Kevine Dongmo Jumeta, Bruno Ndjakou Lenta, Fabrice Fekam Boyom, Andrej Frolov, Norbert Arnold, Ludger A. Wessjohann, Norbert Sewald, Bonaventure Tchaleu Ngadjui, Ghislain Wabo Fotso   +12 more
wiley   +1 more source

Encapsulation of a Hydrophobic Fluorenyl‐Porphyrin in Biocompatible Nanoparticles: Influence of Photosensitizer Loadings on Two‐Photon Phototherapeutic Potential

ChemistryEurope, Volume 4, Issue 3, March 2026.
A new star‐shaped porphyrin (PS), acting as fluorescent two‐photon photosensitizer was encapsulated into biocompatible poly(benzyl malate) nanoparticles (NPs) and tested in vitro on MCF‐7 breast cancer cells in photodynamic therapy and for fluorescence imaging.
Viktoriia Gorbunova, Limiao Shi, Christophe Nguyen, Magali Gary‐Bobo, Nicolas Richy, Frédéric Paul, Olivier Mongin, Sandrine Cammas‐Marion, Christine O. Paul‐Roth   +8 more
wiley   +1 more source

Non‐Starch Purple Sweet Potato Polysaccharide Ameliorates Lipopolysaccharides‐Induced Acute Colitis by Regulating Gut Function and Inactivating the NOD‐Like Receptor Protein 3 Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
Purple sweet potato polysaccharide (PSP) ameliorates lipopolysaccharide‐induced ulcerative colitis in mice through multiple coordinated mechanisms. Oral PSP administration dose‐dependently: (1) Modulates gut microbiota composition and increases short‐chain fatty acid levels; (2) strengthens intestinal barrier function; (3) attenuates systemic ...
Peng Yu, Jitao Ling, Yixuan Chen, Panpan Xia, Yuting Wu, Jianqi Liang, Xuehong Zheng, Yunkun Liu, Zhou Xu, Yiming Gan, Ao Shi, Wenting Wang, Xiao Liu, Yaqi Rong, Yan Xiong, Jianping Liu, Xiaoping Yin, Jing Zhang, Deju Zhang   +18 more
wiley   +1 more source

Unravelling Rheology and Structural Properties of Polysaccharides from Porphyridium Purpureum After Alkali Pre‐Treatment

Macromolecular Bioscience, Volume 26, Issue 3, March 2026.
Porphyridium purpureum polysaccharides are established hydrocolloids among several microalgal biomolecules, however they only exhibit higher viscosity without gelling capacity. Therefore, this study chose to employ alkali pretreatment to Porphyridium purpureum to investigate whether controlled chemical modification could alter the molecular structure ...
Farjana Akter, Anjon Kumar Mondal, Gemma Mestres, Jonas Gustafsson, Peter J. Ralph, Unnikrishnan Kuzhiumparambil   +5 more
wiley   +1 more source

Implementing a Tiered Genetic Testing Strategy for Muscular Dystrophies in Morocco: From Targeted Assays to Exome Sequencing

Molecular Genetics &Genomic Medicine, Volume 14, Issue 3, March 2026.
Targeted routine testing combined with NGS approaches enabled effective genetic diagnosis of muscular dystrophies in Moroccan patients, with nearly half of cases resolved by first‐line testing and additional diagnoses obtained through targeted sequencing and whole‐exome sequencing.
Yasmina Rahmuni, Ilham Ratbi, Jaber Lyahyai, Imane Cherkaoui Jaouad, Ourayna Batta, Aziza Sbiti, Maryem Sahli, Omar Askander, Zineb Rchiad, Abdelaziz Sefiani   +9 more
wiley   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source