Results 31 to 40 of about 107,475 (169)

Biopterin metabolism and eNOS expression during hypoxic pulmonary hypertension in mice. [PDF]

PLoS ONE, 2013
Tetrahydrobiopterin (BH4), which fosters the formation of and stabilizes endothelial NO synthase (eNOS) as an active dimer, tightly regulates eNOS coupling / uncoupling.
Mathilde Dubois, Estelle Delannoy, Lucie Duluc, Ellen Closs, Huige Li, Christian Toussaint, Alain-Pierre Gadeau, Axel Gödecke, Véronique Freund-Michel, Arnaud Courtois, Roger Marthan, Jean-Pierre Savineau, Bernard Muller   +12 more
doaj   +1 more source

Possibility of the Nonenzymatic Conversion of 6-(1'-Oxo-2'-hydroxypropyl)- Tetrahydropterin to Sepiapterin

Pteridines, 2005
Tetrahydrobiopterin (BH4) is a cofactor for aromatic amino acid hydroxylases and nitric oxide synthase. The biosynthetic pathway of BH4 from 6-pyruvoyl-tetrahydropterin (PPH4) includes two reduction steps catalyzed by sepiapterin rcductasc (SPR).
Sawada Hiroshi, Shimura Natumi, Takikawa Shin-Ichiro, Lino Teruhiko   +3 more
doaj   +1 more source

Isolation and Characterization of Sepiapterin Reductase from Drosophila melanogaster

Pteridines, 1993
Sepiapterin reductase, an enzyme that catalyses the synthesis of tetrahydrobiopterin (BH4). was partially purified from Drosophila melanogaster using ammonium sulfate fractionation. Affi-gel blue chromatography and hydroxyapatite chromatography.
Yoon K.H., Cha K.W., Park S.I., Yim J.J.
doaj   +1 more source

A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila. [PDF]

PLoS Biology, 2017
Here, we show that the enzymatic cofactor tetrahydrobiopterin (BH4) inhibits feeding in Drosophila. BH4 biosynthesis requires the sequential action of the conserved enzymes Punch, Purple, and Sepiapterin Reductase (Sptr).
Do-Hyoung Kim, Minjung Shin, Sung-Hwan Jung, Young-Joon Kim, Walton D Jones   +4 more
doaj   +1 more source

Sepiapterin reductase expression is increased in Parkinson's disease brain tissue [PDF]

Brain Research, 2007
Richard H Myers, Ann McKee, Anita L DeStefano   +2 more
exaly   +2 more sources

PARK2 Patient Presenting with Dopa-Responsive Dystonia

Case Reports in Neurology, 2021
We report a 34-year-old female PARK2 patient presenting with dopa-responsive dystonia (DRD). She noticed difficulty in raising her foot while walking at the age of 24.
Fumihito Yoshii, Koji Aono, Ryuya Kumazawa, Wakoh Takahashi   +3 more
doaj   +1 more source

Ruthenium nanomicellar catalysis under MW irradiation” and “Development of an alternative synthetic strategy for Sepiapterin" [PDF]

, 2022
The first project regards the academic research and have the aim to develop new sustainable synthesis through nanomicellar catalytic system assisted with MW irradiation.
Saponaro, Simone
core   +1 more source

A comparative structural analysis of sepiapterin reductase from Drosophila by homology modeling

Pteridines, 2015
Sepiapterin reductase (SR) catalyzes the final steps of BH4 biosynthesis. Previously, a gene encoding SR has been cloned and characterized from a Drosophila cDNA library in vitro.
Kim Kiyoung, Song Keon-Hyoung, Yim Jeongbin   +2 more
doaj   +1 more source

A New Functional Role of 5,6,7,8-tetrahydrobiopterin (BH4) as an Inhibitor of γ-glutamylcysteine Synthetase (γ-GCS) mRNA Expression

Pteridines, 2002
The effect of the intracellular 5,6,7,8-tetrahydrobiopterin (BH4) on the increased γ-glutamylcysteine synthetase (γ-GCS) mRNA expression induced by nitric oxide (NO) was investigated in RAW264.7 cells.
Kojima Shuji, Kurozumi Risa, Tuchiya Maiko   +2 more
doaj   +1 more source

Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH₄ Pathway

, 2019
Tetrahydrobiopterin (BH4) is a cofactor in the production of various signaling molecules including nitric oxide, dopamine, adrenaline, and noradrenaline.
Olivia Jackson (3835966), Jack Blackburn (6939671), Rebecca Armitage (6939668), Patrick C. McHugh (7305878), Benjamin J. R. Moore (6939662), Barira Islam (1430641), Sean Ward (6939665), Shozeb Haider (1411420)   +7 more
core   +3 more sources