Results 61 to 70 of about 107,475 (169)
BH4 Oxidation‐Derived H2O2 Activates ERK1/2 Signaling via B‐Raf in Rat Dorsal Root Ganglion Neurons
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.Tetrahydrobiopterin (BH4) is linked to various pain conditions, but targeting its synthesis in vivo is prone to side effects. We now characterized a so far unknown mechanism of BH4‐induced signaling in sensory neurons. In rat dorsal root ganglion (DRG) neurons, we identified neither BH4 nor its oxidation product, BH2, but the byproduct H2O2 to induce ...
Milad Mohammadi +4 more
wiley +1 more source
Journal of Pineal Research, Volume 77, Issue 5, September 2025.ABSTRACT Melatonin is imperative in animals and plants, contributing to multiple physiological roles, and its microbial production could offer an eco‐friendly alternative to synthetic melatonin. However, detecting and characterizing it in microorganisms remains ongoing, and the biosynthesis pathways are still poorly explored.
Sang‐Mo Kang +5 more
wiley +1 more source
Brain and Behavior, Volume 15, Issue 7, July 2025.Mendelian randomization (MR) analysis was applied to elucidate the causal relationship between immune cell proteins and PD. Our study reveals a possible causal effect of immune cell proteins on the risk of PD and provides new ideas for the prevention and management of PD through immune cell proteins.
Haining Li +7 more
wiley +1 more source
Theoretical Stereostructure of the Neutral Form of Natural Tetrahydrobiopterin
Pteridines, 1993 The absolute conformation and the reactivity of atoms of the neutral form of natural tetrahydrobiopterin [(6R)-6-(L-erythro-1 ′,2′ -dihydroxypropyl)-5.6.7.8-tetrahydropterin] was determined by the Molecular-Orbital method within the MINDO/3 framework ...
Katoh Setsuko +2 more
doaj +1 more source
The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase
Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea +2 more
wiley +1 more source
L-dopa responsive dystonia due to sepiapterin reductase deficiency, a tetrahydrobiopterin deficiency presenting without hyperphenylalaninaemia [PDF]
, 2003 Sepiapterin reductase (SPR) catalyses the last step in the biosynthesis of tetrahydrobiopterin (BH4), the essential cofactor for the aromatic amino acid hydroxylases as well as glycerol-ether monooxygenase and the three isoforms of nitric oxide ...
35th European Human Genetics Conference (ESHG) +5 more
core
Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery
Antibiotics, 2014 The need for new antimicrobials is great in face of a growing pool of resistant pathogenic organisms. This review will address the potential for antimicrobial therapy based on polypharmacological activities within the currently utilized bacterial ...
Christina R. Bourne
doaj +1 more source
An Unusual Motor OFF in Parkinson's Disease
Movement Disorders Clinical Practice, Volume 13, Issue 4, Page 1085-1087, April 2026.
Shreyashi Jha, Mandar S. Jog
wiley +1 more source
Helicobacter, Volume 30, Issue 2, March/April 2025.ABSTRACT Background Helicobacter pylori (H. pylori) has been identified as a type I carcinogen and contributes to a high rate of gastric cancer (GC), especially in Eastern Asia. Extracellular vesicles (EVs) have the potential to be used to detect various cancer types and diseases. However, the protein markers in EVs for the prognosis of H.
Phawinee Subsomwong +5 more
wiley +1 more source
Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH₄ Pathway [PDF]
, 2019 Tetrahydrobiopterin (BH4) is a cofactor in the production of various signaling molecules including nitric oxide, dopamine, adrenaline, and noradrenaline.
Armitage, R +7 more
core +1 more source