Results 131 to 140 of about 536,044 (309)

Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner [PDF]

Sepsis affects 25 million children per year globally, leading to 2.9 million deaths and substantial disability in survivors. Extensive characterization of interactions between the host and bacteria in children is required to design novel preventive and ...
Fraser, Donald J, Papadopoulou, M., Schlapbach, L.J., Agyeman, PKA, Miners, Kelly L, Vermijlen, D., Price, D.A., Sanchez, Guillem Sanchez, Price, David A, McLaren, James E., Rezwani, M., Rezwani, Moosa, Vermijlen, David, Schlapbach, Luregn J, Ladell, K., Fraser, Donald J., Sanchez Sanchez, G., Agyeman, Philipp K A, Giannoni, E., Fraser, D.J., McLaren, J.E., Eberl, Matthias, McLaren, James E, Schlapbach, Luregn, Ahmed, R., Study, Swiss Pediatric Sepsis, Swiss Pediatric Sepsis Study, Sanchez Sanchez, Guillem, Verdebout, I., Miners, Kelly L., Agyeman, Philipp K.A., McLaren, James J.E., Ladell, Kristin, Miners, K.L., Schlapbach, Luregn Jan, Verdebout, Isoline, Papadopoulou, Maria, Price, David A., Giannoni, Eric, Eberl, M., Ahmed, Raya   +40 more
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Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Association analysis of rare variants in human Sepsis [PDF]

openSepsis is a highly lethal syndrome resulting from abnormal immune and metabolic responses to infection, thereby compromising host homeostasis.
ZEGGANE, SMAIL SYPHAX
core  

Soft, Multi‐Wavelength Photoplethysmography Enables Reliable Neonatal Blood Pressure Monitoring Via Error Stratification

Advanced Science, EarlyView.
A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi, Lanlan Mi, Jiarong Chen, Biao Liu, Min Wang, Zisheng Dai, Bin Liu, Ruize Gao, Yunfeng Lin, Weiwei Guo, Guoxing Wang, Wenyi Luo, Cheng Chen   +12 more
wiley   +1 more source

Characteristics of Anal Fistula Cancer in Patients Who Underwent Surgery: A Nationwide Observational Study Using Diagnosis Procedure Combination Data

Annals of Gastroenterological Surgery, EarlyView.
The characteristics of patients with anal fistula cancer included a higher proportion of men, younger age, more smokers, and tumor‐related characteristics, including more advanced local progression. Surgical characteristics included a lower rate of minimally invasive surgery, a higher proportion of total pelvic exenterations, and longer postoperative ...
Nobuaki Hoshino, Hiromitsu Kinoshita, Kazutaka Obama, Kiyohide Fushimi, Susumu Kunisawa, Yuichi Imanaka   +5 more
wiley   +1 more source

Sepsis [PDF]

, 2009
Sepsis is the systemic response to infection, usually caused by bacterial infections (both Gram positive and Gram negative). It is a common condition with an overall mortality of about 30%, even when treated appropriately.
Jonathan Cohen (26835)
core   +2 more sources

Relationship Between Hospital Volume and Outcomes of Minimally Invasive Esophagectomy for Esophageal Cancer: Analysis of the National Clinical Database in Japan

Annals of Gastroenterological Surgery, EarlyView.
According to multivariable analysis conducted using a hierarchical logistic regression model, using VHH as the reference group, the odds ratios for mortality by hospital volume category were as follows: VLH, 2.70 (p < 0.0001); LH, 1.72 (p = 0.052); MH, 1.70 (p = 0.034); and HH, 1.43 (p = 0.173).
Soji Ozawa, Hiraku Kumamaru, Yuko Kitagawa, Kazuo Koyanagi, Junya Oguma, Harushi Udagawa, Hiroaki Miyata, Yasushi Toh, Hisahiro Matsubara   +8 more
wiley   +1 more source

Lymphocyte‐C‐Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Surgical site infection (SSI) is a major complication after ileal pouch–anal anastomosis (IPAA) in pediatric ulcerative colitis (UC), significantly impairing quality of life. The lymphocyte‐to–C‐reactive protein ratio (LCR), a composite marker of systemic inflammation and immune/nutritional status, has emerged as a potential ...
Yuhki Koike, Koki Higashi, Yuki Sato, Yuka Nagano, Tadanobu Shimura, Takahito Kitajima, Kohei Matsushita, Yoshiki Okita, Yoshinaga Okugawa, Yuji Toiyama   +9 more
wiley   +1 more source

Making health care safer : Think sepsis. Time matters [PDF]

Sepsis is a complication caused by the body\ue2\u20ac\u2122s overwhelming and life-threatening response to infection. It can lead to tissue damage, organ failure, and death. Sepsis is difficultto diagnose.

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