Results 131 to 140 of about 583,528 (304)
Advanced Science, EarlyView.In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang +8 more
wiley +1 more source
MicroRNA Profiles in Intestinal Epithelial Cells in a Mouse Model of Sepsis [PDF]
三重大学博士(医学)application/pdfAbstract: Sepsis is a systemic inflammatory disorder that leads to the dysfunction of multiple organs. In the intestine, the deregulation of the epithelial barrier contributes to the development of sepsis by triggering continuous
CAIDENGBATE, SIQINGAOWA
core +1 more source
Advanced Science, EarlyView.Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu +6 more
wiley +1 more source
BackgroundThe integration of digital healthcare and electronic health records promises to advance sepsis care through data-driven approaches and artificial intelligence (AI).
Raisaro, Jean Louis +15 more
core +1 more source
Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy
Advanced Science, EarlyView.Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao +2 more
wiley +1 more source
Pharmacological Treatment of Sepsis and Septic Shock
, 2017 The subject of this thesis is a short review on the newest updates and guidelines on the subject of Treatment of sepsis and septic shock. It is broken down into first definition and pathophysiology of sepsis and then goes into current guidelines of ...
Sævarsson, Ívar
core
Pharmacological treatment options in sepsis
, 2022 Sepsis is a common life-threatening condition characterised by organ dysfunction caused by dysregulated host immune response to infection. For patients with sepsis and septic shock therapeutic priorities include securing the airway, correcting hypoxia ...
Grétarsdóttir, Elva Eir
core
Advanced Science, EarlyView.Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li +7 more
wiley +1 more source
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Physiological ReportsIschemia‐reperfusion (IR) is a leading cause of acute kidney injury (AKI), and pigs are commonly used in preclinical AKI models. However, existing models often vary in the methods used to induce ischemia, and the resulting AKI tends to be mild‐to ...
Axel Guilpin +9 more
doaj +1 more source