Results 61 to 70 of about 326,876 (283)

Double orifice mitral valve associated with Ventricular Septal Defect in an infant : case report [PDF]

, 2011
Double orifice mitral valve (DOMV) is an uncommon anomaly characterized by a mitral valve with a single fibrous annulus with two orifices opening into the left ventricle.
Taksande, Amar M., Thomas, E., Goutami, V.   +2 more
core  

Incidence and risk factors of cancer in individuals with cystic fibrosis in the UK; a case-control study. [PDF]

, 2021
To assess cancer incidence in the UK cystic fibrosis (CF) population and determine the associated risk factors, we undertook a nested case-control study of patients with CF, registered with the UK CF Registry.
Mentzakis, Emmanouil, Peckham, Daniel, Cullinan, P., Mentzakis, E., Carr, S.B., Bilton, D., Simmonds, Nicholas J, Archangelidi, Olga, Archangelidi, O., Simmonds, N.J., Bilton, Diana, Simmonds, N. J., Peckham, D., Carr, S. B., Cullinan, Paul, Carr, Siobhán B   +15 more
core   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Cardiac risk and myocardial fibrosis assessment with cardiac magnetic resonance in patients with myotonic dystrophy

Frontiers in Neurology
IntroductionNon-invasive evaluation of myocardial tissue is a major goal of cardiac imaging. This is the case of myocardial fibrosis which is crucial in many myocardial diseases.
Elena Abati, Elena Abati, Claudia Alberti, Valentina Tambè, Anastasia Esseridou, Giacomo Pietro Comi, Giacomo Pietro Comi, Stefania Corti, Stefania Corti, Giovanni Meola, Giovanni Meola, Francesco Secchi, Francesco Secchi   +12 more
doaj   +1 more source

Diffuse interstitial fibrosis assessed by cardiac magnetic resonance is associated with dispersion of ventricular repolarization in patients with hypertrophic cardiomyopathy

Journal of Arrhythmia, 2017
Background: Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy, disarray, fibrosis, and increased risk for ventricular arrhythmias.
David Hurtado-de-Mendoza, MD, Celia P. Corona-Villalobos, MD, Iraklis Pozios, MD, Jorge Gonzales, MD, Yalda Soleimanifard, MD, Sanjay Sivalokanathan, MD, Diego Montoya-Cerrillo, MD, Styliani Vakrou, MD, Ihab Kamel, MD, Wilfredo Mormontoy-Laurel, MD, Ketty Dolores-Cerna, MD, Jacsel Suarez, MD, Sergio Perez-Melo, MD, David A. Bluemke, MD, Theodore P. Abraham, MD, Stefan L. Zimmerman, MD, M. Roselle Abraham, MD   +16 more
doaj   +1 more source

Delayed Amplatzer device closure of atrial septal defect for persistent cyanosis after surgical correction of severe pulmonary stenosis in early infancy [PDF]

, 2004
This article presents two patients who had delayed transcatheter closure of secundum atrial septal defects for persistent cyanosis after surgical repair of severe pulmonary stenosis.
DeGiovanni, Joseph V., Grech, Victor E., Falzon, A.   +2 more
core  

Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis [PDF]

, 2010
Background: FibroTest (FT) is the most frequently used serum fibrosis marker and consists of an algorithm of five fibrosis markers (alfa2-macroglobulin, apolipoproteinA1, haptoglobin, GGT, bilirubin). The Enhanced Liver Fibrosis (ELF) test consists of an
Julie Parkes, Stefan Zeuzem, Herrmann, Eva, Friedrich-Rust, Mireen, William Rosenberg, Sarrazin, Christopher, Mireen Friedrich-Rust, Sarrazin, Christoph, Christoph Sarrazin, Parkes, Julie, Eva Herrmann, Rosenberg, William, Zeuzem, Stefan   +12 more
core   +2 more sources

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis in rats Papel da hepatectomia parcial sobre a fibrose septal do fígado induzida pela Capillaria hepatica em ratos

Revista da Sociedade Brasileira de Medicina Tropical, 2007
It is known that hepatic fibrosis may regress following partial hepatectomy, since the hepatic parenchyma regenerates very rapidly, but not the excess of fibrous tissue.
Carolina Cincurá Silva Santos, Záira Onofre-Nunes, Zilton Araujo Andrade   +2 more
doaj   +1 more source

Correlation between septal midwall late gadolinium enhancement on CMR and conduction delay on ECG in patients with nonischemic dilated cardiomyopathy

International Journal of Cardiology: Heart & Vasculature, 2020
Background: Septal midwall late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) is a characteristic finding in nonischemic dilated cardiomyopathy (DCM) and is associated with adverse cardiac events.
Marthe A.J. Becker, Cornelis P. Allaart, Alwin Zweerink, Jan H. Cornel, Peter M. van de Ven, Albert C. van Rossum, Tjeerd Germans   +6 more
doaj   +1 more source