Results 1 to 10 of about 187,691 (216)

Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats

Acta Pharmaceutica Sinica B, 2020
Hepatic fibrosis is one kind of liver diseases with a high mortality rate and incidence. The activation and proliferation of hepatic stellate cells (HSCs) is the most fundamental reason of hepatic fibrosis.
Yao Fu, Tijia Chen, Zhirong Zhang
exaly   +3 more sources

New Drugs for Hepatic Fibrosis

Frontiers in Pharmacology, 2022
The morbidity and mortality of hepatic fibrosis caused by various etiologies are high worldwide, and the trend is increasing annually. At present, there is no effective method to cure hepatic fibrosis except liver transplantation, and its serious ...
Liang Shan, Jianjun Liu, Xiongwen Lv
exaly   +3 more sources

Recent Advances in the Study of Traditional Chinese Medicine in Reversing Hepatic Fibrosis Through the Regulation of Hepatic Stellate Cells Apoptosis Pathways [PDF]

Drug Design, Development and Therapy
Ruihan Cheng, Baolong Li Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, 150006, People’s Republic of ChinaCorrespondence: Baolong Li, Drug Safety Evaluation Center, Heilongjiang University of ...
Cheng R, Li B
doaj   +2 more sources

Research Progress of Structure, Function and Mechanism of Action of Mitofusin 2 in Liver Diseases [PDF]

Zhongguo quanke yixue, 2023
The liver is the largest metabolic organ in the human body, and impaired liver function can lead to a variety of acute and chronic liver diseases, which can affect the quality of life in mild cases or be life-threatening in severe cases. Therefore, it is
YUAN Xiwei, NAN Yuemin
doaj   +1 more source

Pathogenesis of Viral Hepatitis-Induced Chronic Liver Disease: Role of Extracellular Vesicles

Frontiers in Cellular and Infection Microbiology, 2020
Extracellular vesicles are encapsulated lipid nanoparticles secreted by a variety of cell types in living organisms. They are known to carry proteins, metabolites, nucleic acids, and lipids as their cargoes and are important mediators of intercellular ...
Hong Kiat Lim, Gary P. Jeffrey, Gary P. Jeffrey, Grant A. Ramm, Grant A. Ramm, Carolina Soekmadji, Carolina Soekmadji   +6 more
doaj   +1 more source

Programmed cell death in hepatic fibrosis: current and perspectives

Cell Death Discovery, 2023
The initiation, development and resolution of hepatic fibrosis are influenced by various cytokines, chemokines, damage-associated molecular patterns (DAMPs) and signaling pathways.
Ju-Lu Lu, Chuan-Xin Yu, Li-Jun Song
doaj   +1 more source

Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress

Frontiers in Cell and Developmental Biology, 2021
Hepatic fibrosis is the final pathway of several chronic liver diseases, which is characterized by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of hepatic stellate cells and oxidative stress (OS) play an important
Wenzhang Dai, Wenzhang Dai, Qin Qin, Zhiyong Li, Li Lin, Ruisheng Li, Zhie Fang, Yanzhong Han, Wenqing Mu, Lutong Ren, Tingting Liu, Xiaoyan Zhan, Xiaoyan Zhan, Xiaohe Xiao, Xiaohe Xiao, Xiaohe Xiao, Zhaofang Bai, Zhaofang Bai   +17 more
doaj   +1 more source

Utility and limitations of Hepascore and transient elastography to detect advanced hepatic fibrosis in HFE hemochromatosis

Scientific Reports, 2021
Aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 Index (Fib4) have been validated against liver biopsy for detecting advanced hepatic fibrosis in HFE hemochromatosis.
Sim Yee Ong, Tiffany Khoo, Amanda J. Nicoll, Lyle Gurrin, Thomas Worland, Puraskar Pateria, Louise E. Ramm, Adam Testro, Gregory J. Anderson, Richard Skoien, Lawrie W. Powell, Grant A. Ramm, John K. Olynyk, Martin B. Delatycki   +13 more
doaj   +1 more source

Advances on Nanomedicines for Diagnosis and Theranostics of Hepatic Fibrosis

Advanced NanoBiomed Research, 2021
Hepatic fibrosis is induced by chronic hepatic injuries before it turns into hepatic cirrhosis/carcinoma. It is characterized by the formation of collagen and other extracellular matrices around damaged hepatic tissues; consequently, the normal ...
Xinghang Dai, Yujun Zeng, Hu Zhang, Zhongwei Gu, Qiyong Gong, Kui Luo   +5 more
doaj   +1 more source

DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway

Pharmacological Research, 2023
Hepatic fibrosis is caused by liver damage as a consequence of wound healing response. Recent studies have shown that hepatic fibrosis could be effectively reversed, partly through regression of activated hepatic stellate cells (HSCs).
Liangyun Li, Shaoxi Diao, Zixiang Chen, Jintong Zhang, Wei Chen, Tianqi Wang, Xin Chen, Yuxin Zhao, Tao Xu, Cheng Huang, Jun Li   +10 more
doaj   +1 more source