Reversibility of hepatic fibrosis
, 2014 • Although chronic hepatitis has a diverse aetiology, development of hepatic fibrosis is the universal outcome. • Cirrhosis is considered to be the universal end-stage of chronic liver disease.
Sonneveld, Milan J. +3 more
core +10 more sources
Cystic fibrosis related chronic liver disease: a study of its influence upon prognosis and possible mechanisms for this; with specific reference to pulmonary and systemic haemodynamics [PDF]
, 1995 MDTo assess the influence of chronic liver disease on survival a time dependent multivariate Cox regression analysis was It performed. The results confirmed that patients with evidence of chronic liver disease have a worse prognosis.
Williams, Simon Graham John
core +4 more sources
Advances on Nanomedicines for Diagnosis and Theranostics of Hepatic Fibrosis
Advanced NanoBiomed Research, 2021 Hepatic fibrosis is induced by chronic hepatic injuries before it turns into hepatic cirrhosis/carcinoma. It is characterized by the formation of collagen and other extracellular matrices around damaged hepatic tissues; consequently, the normal ...
Xinghang Dai +5 more
doaj +1 more source
Pharmacological Research, 2023 Hepatic fibrosis is caused by liver damage as a consequence of wound healing response. Recent studies have shown that hepatic fibrosis could be effectively reversed, partly through regression of activated hepatic stellate cells (HSCs).
Liangyun Li +10 more
doaj +1 more source
Autophagy in Hepatic Fibrosis [PDF]
BioMed Research International, 2014 Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking.
Yang Song +5 more
openaire +2 more sources
Noninvasive diagnosis of pediatric nonalcoholic fatty liver disease [PDF]
Korean Journal of Pediatrics, 2013 Because nonalcoholic steatohepatitis can progress towards cirrhosis even in children, early detection of hepatic fibrosis and accurate diagnosis of nonalcoholic fatty liver disease (NAFLD) are important.
Hye Ran Yang
doaj +1 more source
Autoimmune Hepatitis and Fibrosis
Journal of Clinical Medicine, 2023 Autoimmune hepatitis (AIH) is a chronic immune-inflammatory disease of the liver, generally considered a rare condition. The clinical manifestation is extremely varied and can range from paucisymptomatic forms to severe hepatitis. Chronic liver damage causes activation of hepatic and inflammatory cells leading to inflammation and oxidative stress ...
Rinaldo Pellicano +5 more
openaire +2 more sources
Hepatic Fibrosis in Dogs [PDF]
Journal of Veterinary Internal Medicine, 2018 Abstract Hepatic fibrosis is commonly diagnosed in dogs, often as a sequela to chronic hepatitis (CH). The development of fibrosis is a crucial event in the progression of hepatic disease that is of prognostic value. The pathophysiology of hepatic fibrosis in human patients and rodent models has been studied extensively. Although less
V.M. Eulenberg, J.A. Lidbury
openaire +2 more sources
N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells] [PDF]
, 2004 Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix ...
Iredale, John P. +15 more
core +1 more source
Serum proteome profiling identifies novel and powerful markers of cystic fibrosis liver disease. [PDF]
, 2013 Cystic Fibrosis associated liver disease (CFLD) develops in approximately 30% of CF patients. However, routine sensitive diagnostic tools for CFLD are lacking. Within this study, we aimed to identify new experimental biomarkers for the detection of CFLD.
Richard Schulz +26 more
core +1 more source