Results 51 to 60 of about 29,905 (235)

Hypertrophic cardiomyopathy

International Journal of Cardiology: Heart & Vasculature, 2020
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease. The disease is characterized by marked variability in morphological expression and natural history, ranging from asymptomatic to heart failure or sudden cardiac death.
Murillo de Oliveira Antunes, Thiago Luis Scudeler   +1 more
doaj   +1 more source

Current therapies for hypertrophic cardiomyopathy: a systematic review and meta‐analysis of the literature

ESC Heart Failure, 2023
Aims The aim of this study was to synthesize the evidence on the effect of the current therapies over the pathophysiological and clinical characteristics of patients with hypertrophic cardiomyopathy (HCM). Methods and results A systematic review and meta‐
Adrián Bayonas‐Ruiz, Francisca María Muñoz‐Franco, María Sabater‐Molina, María José Oliva‐Sandoval, Juan R. Gimeno, Bárbara Bonacasa   +5 more
doaj   +1 more source

PULMONARY HYPERTENSION IN HYPERTROPHIC CARDIOMYOPATHY: EFFECT OF SEPTAL REDUCTION THERAPY

Journal of the American College of Cardiology, 2013
Within hypertrophic cardiomyopathy (HCM), pulmonary hypertension can result from diastolic dysfunction and from a contraction load on the left ventricle secondary to obstruction with associated mitral regurgitation.
Geske, Jeffrey B., Konecny, Tomas, Ommen, Steve, Nishimura, Rick, Gersh, Bernard   +4 more
openaire   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Clinical burden of obstructive hypertrophic cardiomyopathy in France

Frontiers in Cardiovascular Medicine
BackgroundHypertrophic cardiomyopathy (HCM) can be genetic and occurs as obstructive and non-obstructive 21 subtypes. Little is known about the clinical burden of the obstructive subtype of HCM at a national 22 level, and how it may differ by New York ...
Philippe Charron, Carla Zema, François-Emery Cotté, Eléonore Herquelot, Taryn Krause, Florent Daydé, Jean-Noël Trochu   +6 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Micro-coil embolization for transcatheter septal ablation in a hypertrophic obstructive cardiomyopathy patient and an unusual coronary anatomy: a case report

Frontiers in Cardiovascular Medicine
BackgroundTranscatheter septal ablation is a minimally invasive therapeutic method for treating symptomatic obstructive hypertrophic cardiomyopathy (HCM).
Aleksandar Mandic, Gorica Vidovic, Dragana Radoicic, Ivan Ilic, Ivan Ilic   +4 more
doaj   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics

Advanced Science, EarlyView.
stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang, Yan Wang, Luonan Chen, Chunman Zuo   +3 more
wiley   +1 more source

The evolving clinical practice of septal reduction therapy in hypertrophic obstructive cardiomyopathy

International Journal of Surgery
Hypertrophic obstructive cardiomyopathy remains a formidable clinical challenge, and septal reduction therapy (SRT) continues to be the cornerstone for managing drug-refractory left ventricular outflow tract obstruction. Over the past decade, SRT has undergone remarkable refinement and diversification.
Xin, Zhang, Yuji, Xie, Lingyun, Fang, Jia, Xu, Yun, Yang, Zixuan, He, Yinting, Xiong, Manxin, Huang, Qing, Lv, Mingxing, Xie, Wenqian, Wu   +10 more
openaire   +2 more sources