Results 71 to 80 of about 5,703,192 (247)

Interventions for Hypertrophic Obstructive Cardiomyopathy: Defining the Gold Standard, Assessing Durability, and Guiding Patient Selection

Medical Sciences
Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic disorder characterized by a dynamic left ventricular outflow tract (LVOT) obstruction and an increased risk of sudden cardiac death.
Ajibola Anifowose, Marco Tagliafierro, Ghadeer Mahdi, Saada Hussein, Massimo Baudo, Tulio Caldonazo, Aleksander Dokollari, Kaveh Hosseini, William D. T. Kent, Ali Fatehi Hassanabad   +9 more
doaj   +1 more source

Septal Reduction Therapy for Hypertrophic Obstructive Cardiomyopathy

, 2010
Hypertrophic obstructive cardiomyopathy can cause symptoms such as dyspnoea, angina pectoris and syncope. First-line pharmacological therapy includes betablockers, verapamil and disopyramid.
Ulrich Sigwart, Amir-Ali Fassa
core   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Effects of Alcohol Septal Ablation on Exercise Hemodynamics, Symptoms, and Quality of Life in Obstructive Hypertrophic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The impact of alcohol septal ablation (ASA) on exercise hemodynamics, symptoms, and quality of life in patients with obstructive hypertrophic cardiomyopathy is poorly described according to contemporary standards.
Anne M. Dybro, Torsten B. Rasmussen, Roni R. Nielsen, Bertil T. Ladefoged, Anders L. D. Pedersen, Christian J. Terkelsen, Mads J. Andersen, Morten K. Jensen, Steen H. Poulsen   +8 more
doaj   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

Genetically Modulated Substrate Reduction Therapy for Sanfilippo Syndrome: Proof of Principle [PDF]

, 2018
About proof of principle in genetically modulated substrate reduction therapy for Sanfilippo syndrome.FCT SFRH/BPD/101965/2014; SFRH/BD/124372/2016N/
Alves, Sandra, Gaspar, Paulo, Gaspar, P., Coutinho, Maria Francisca, Santos, Juliana Inês, Alves, S., Santos, J.I.   +6 more
core  

Adverse response to cardiac resynchronisation therapy in patients with septal scar on cardiac MRI preventing a septal right ventricular lead position

, 2011
Purpose  Myocardial scar is an adverse factor when considering which patients are likely to respond to cardiac resynchronisation therapy (CRT). We hypothesized that septal scarring on magnetic resonance imaging (MRI) may be associated with a poor outcome
Reza Razavi, Gill, Jaswinder, Kirubakaran, Senthil, Matthew Ginks, Duckett, Simon G., Senthil Kirubakaran, Simon G. Duckett, Shetty, Anoop, Jaswinder Gill, Ginks, Matthew, Julian Bostock, Razavi, Reza; id_orcid, Rinaldi, Christopher Aldo, Carr-White, Gerald, Bostock, Julian, Kapetanakis, Stamatis, C. Aldo Rinaldi, Stam Kapetanakis, Gerry Carr-White, Anoop Shetty   +19 more
core   +1 more source

Engineering a Bioelectronic Hybrid Heart with Integrated Sensing and Electrical Modulation

Advanced Science, EarlyView.
A bioelectronic hybrid heart is engineered by integrating iPSC‐derived cardiomyocytes, a decellularized cardiac scaffold, a cell‐laden ECM coating, and a flexible electronic mesh. The embedded electrodes enable real‐time recording of spontaneous electrical activity and localized stimulation, allowing controlled pacing and modulation of activation ...
Itai Cabilly, Hadas Oved, Ron Feiner, Nadav Noor, Moran Yadid, Melanie Flury, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Outcomes After Repeat Alcohol Septal Ablation in Patients With Obstructive Hypertrophic Cardiomyopathy

JACC: Advances
Background: Alcohol septal ablation (ASA) may necessitate a repeat procedure if the obstructive myocardium is not sufficiently ablated; however, the outcomes after repeat ASA are not well studied.
Takashi Hiruma, MD, Mitsunobu Kitamura, MD, Itaru Takamisawa, MD, Ryo Abe, MD, Tosei Kawai, MD, Takashi Funaki, MD, Yuki Izumi, MD, Ryosuke Higuchi, MD, Junya Matsuda, MD, Yukichi Tokita, MD, Mamoru Nanasato, MD, Nobuo Iguchi, MD, Tomohiro Iwakura, MD, Tomoki Shimokawa, MD, Shuichiro Takanashi, MD, Hiroo Takayama, MD, PhD, Yuichi J. Shimada, MD, MPH, Hitoshi Takano, MD, Kuniya Asai, MD, Mitsuaki Isobe, MD, Morimasa Takayama, MD   +20 more
doaj   +1 more source