Results 61 to 70 of about 5,703,192 (247)

Current therapies for hypertrophic cardiomyopathy: a systematic review and meta‐analysis of the literature

ESC Heart Failure, 2023
Aims The aim of this study was to synthesize the evidence on the effect of the current therapies over the pathophysiological and clinical characteristics of patients with hypertrophic cardiomyopathy (HCM). Methods and results A systematic review and meta‐
Adrián Bayonas‐Ruiz, Francisca María Muñoz‐Franco, María Sabater‐Molina, María José Oliva‐Sandoval, Juan R. Gimeno, Bárbara Bonacasa   +5 more
doaj   +1 more source

Double orifice mitral valve associated with Ventricular Septal Defect in an infant : case report [PDF]

, 2011
Double orifice mitral valve (DOMV) is an uncommon anomaly characterized by a mitral valve with a single fibrous annulus with two orifices opening into the left ventricle.
Taksande, Amar M., Thomas, E., Goutami, V.   +2 more
core  

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Alcohol Septal Ablation: An Option on the Rise in Hypertrophic Obstructive Cardiomyopathy

, 2021
Hypertrophic cardiomyopathy (HCM) can cause symptoms due to the obstruction of the left ventricle outflow tract (LVOT). Although pharmacological therapy is the first step for treating this condition, many patients do not fully respond to the treatment ...
Manel Sabaté, Francesco Costa, Mónica Masotti, Salvatore Brugaletta, Ander Regueiro, Victor Arévalos, Juan José Rodríguez-Arias, Xavier Freixa, Antonio Micari, Regueiro A., Micari A., Brugaletta S., Masotti M., Arevalos V., Rodriguez-arias J. J., Sabate M., Costa F., Freixa X.   +17 more
core   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Delayed Amplatzer device closure of atrial septal defect for persistent cyanosis after surgical correction of severe pulmonary stenosis in early infancy [PDF]

, 2004
This article presents two patients who had delayed transcatheter closure of secundum atrial septal defects for persistent cyanosis after surgical repair of severe pulmonary stenosis.
DeGiovanni, Joseph V., Grech, Victor E., Falzon, A.   +2 more
core  

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Phenotype-Based Classification of Obstructive Hypertrophic Cardiomyopathy Undergoing Myectomy

JACC: Basic to Translational Science
Summary: This study partitioned variables derived from clinical and pathological information in patients who received septal reduction therapy to identify obstructive hypertrophic cardiomyopathy subtypes.
Hao Cui, PhD, Hao Nie, MD, PhD, Congrui Wang, MD, Ningning Zhang, MSc, Yifan Wang, MD, PhD, Wendao Liu, PhD, Siyuan Huang, MD, PhD, Xiao Chen, PhD, Hao Jia, MD, PhD, Songren Shu, MD, PhD, Mengxia Fu, MD, PhD, Qian Zhao, MSc, Xiumeng Hua, MD, PhD, Yuan Chang, MD, PhD, Yunhu Song, MD, PhD, Jiangping Song, MD, PhD   +15 more
doaj   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source