Results 121 to 130 of about 1,087,361 (389)

Clinical characteristics and risk factors for septic shock in patients receiving emergency drainage for acute pyelonephritis with upper urinary tract calculi

BMC Urology, 2012
Background Acute pyelonephritis (APN) is a common complication of ureteral obstruction caused by urolithiasis, and it can be lethal if it progresses to septic shock.
Yamamoto Yoshiyuki, Fujita Kazutoshi, Nakazawa Shigeaki, Hayashi Takuji, Tanigawa Go, Imamura Ryoichi, Hosomi Masahiro, Wada Daiki, Fujimi Satoshi, Yamaguchi Seiji   +9 more
doaj   +1 more source

Treatment of Gram-Negative Septic Shock with Human IgG Antibody to Escherichia coli J5: A Prospective, Double-Blind, Randomized Trial [PDF]

, 2017
In a randomized, double-blind, multicenter trial we compared the efficacy of a preparation of human IgG antibody to Escherichia coli 15 (J5-IVIG) with that of a standard IgG preparation (IVIG) for the treatment of gram-negative septic shock.
Calandra, Thierry, Glauser, Michel P., Schellekens, Joop, Verhoef, Jan   +3 more
core  

Left ventricular systolic function evaluated by strain echocardiography and relationship with mortality in patients with severe sepsis or septic shock. a systematic review and meta-analysis [PDF]

, 2018
Sepsis-induced myocardial dysfunction is associated with poor outcomes, but traditional measurements of systolic function such as left ventricular ejection fraction (LVEF) do not directly correlate with prognosis.
Arcadipane, A, Cecconi, M, Corredor, C, Fletcher, N, Lorini, F L, Sanfilippo, F, Tritapepe, L, Vieillard-Baron, A   +7 more
core   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Noninvasive ventilation failure in patients with hypoxemic respiratory failure: the role of sepsis and septic shock

Therapeutic Advances in Respiratory Disease, 2019
Background: Sepsis and septic shock are common in noninvasive ventilation (NIV) patients. However, studies on the association between sepsis and NIV failure are lacking.
Jun Duan, Lijuan Chen, Guopeng Liang, Weiwei Shu, Liucun Li, Ke Wang, Shengyu Wang, Xiaoyi Liu, Chunfeng He, Dehua He, Qimin Chen, Bilin Wei, Baixu Chen, Yuzhen Shu, Yao Tian, Liping Fan, Xiaoli Han, Rui Zhang, Xiangmei Yang, Yan Peng, Dong Wan, Xiaoying Chen, Lin Ye, Shijing Tian, Qiong Huang, Lei Jiang, Linfu Bai, Lintong Zhou   +27 more
doaj   +1 more source

Fluid therapy and hemodynamic support in septic shock

Journal of Pediatric Critical Care, 2018
Sepsis remains one of the leading causes of mortality in children all over the world, especially in the developing nations. Early recognition of sepsis and septic shock facilitate the resuscitation, further reducing the morbidity and mortality related to
Milind Jambagi, Rakshay Shetty
doaj   +1 more source

Goal-directed resuscitation for patients with early septic shock.

New England Journal of Medicine, 2014
BACKGROUND Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness
S. Peake, A. Delaney, M. Bailey, R. Bellomo, P. Cameron, D. J. Cooper, A. Higgins, A. Holdgate, B. Howe, S. Webb, Patricia Williams   +10 more
semanticscholar   +1 more source

Cerebral microcirculation is impaired during sepsis: an experimental study [PDF]

, 2010
INTRODUCTION: Pathophysiology of brain dysfunction due to sepsis remains poorly understood. Cerebral microcirculatory alterations may play a role; however, experimental data are scarce.
Charalampos Pierrakos, Daniel De Backer, Fabio Silvio Taccone, Fuhong Su, Jean-Louis Vincent, Olivier Dewitte, Syril James, Xinrong He   +7 more
core   +2 more sources

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Surviving sepsis campaign: research priorities for sepsis and septic shock

Intensive Care Medicine, 2018
ObjectiveTo identify research priorities in the management, epidemiology, outcome and underlying causes of sepsis and septic shock.DesignA consensus committee of 16 international experts representing the European Society of Intensive Care Medicine and ...
C. Coopersmith, D. De Backer, C. Deutschman, R. Ferrer, I. Lat, F. Machado, G. Martin, I. Martín-Loeches, M. Nunnally, M. Antonelli, Laura Evans, J. Hellman, S. Jog, J. Kesecioglu, M. Levy, A. Rhodes   +15 more
semanticscholar   +1 more source