Results 121 to 130 of about 1,124,600 (388)

Left ventricular systolic function evaluated by strain echocardiography and relationship with mortality in patients with severe sepsis or septic shock. a systematic review and meta-analysis [PDF]

, 2018
Sepsis-induced myocardial dysfunction is associated with poor outcomes, but traditional measurements of systolic function such as left ventricular ejection fraction (LVEF) do not directly correlate with prognosis.
Arcadipane, A, Cecconi, M, Corredor, C, Fletcher, N, Lorini, F L, Sanfilippo, F, Tritapepe, L, Vieillard-Baron, A   +7 more
core   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Lactate concentration gradient from right atrium to pulmonary artery: a commentary [PDF]

, 2005
Inadequate myocardial performance is a common complication of severe sepsis. Studies in humans strongly argue against a decrease in coronary blood flow in the pathogenesis of this sepsis-induced cardiac injury.
Creteur, Jacques
core   +2 more sources

Effect of Glucose-Insulin-Potassium Infusion on Hemodynamics in Patients with Septic Shock

, 2021
H. Effat, Ramy Khaled, Ahmed A. Battah, Mohamed Shehata, Waleed Farouk   +4 more
openalex   +2 more sources

A Machine Learning Algorithm to Predict Severe Sepsis and Septic Shock: Development, Implementation, and Impact on Clinical Practice.

Critical Care Medicine, 2019
OBJECTIVES Develop and implement a machine learning algorithm to predict severe sepsis and septic shock and evaluate the impact on clinical practice and patient outcomes.
MD Heather M. Giannini, MD Jennifer C. Ginestra, PhD Corey Chivers, BS Michael Draugelis, Mph Asaf Hanish, MD William D. Schweickert, M. M. Barry D. Fuchs, RN Ccrn Laurie Meadows, RN Cen Michael Lynch, R. M. C. Patrick J. Donnelly, Msn Crnp Kimberly Pavan, MD Neil O. Fishman, M. I. C. William Hanson, MD Craig A. Umscheid   +13 more
semanticscholar   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

WHO guidelines on fluid resuscitation in children: missing the FEAST data. [PDF]

, 2014
The World Health Organization recommendations on management of common childhood illnesses affect the lives of millions of children admitted to hospital worldwide.
Akech, SO, Babiker, AG, Crawley, J, Engoru, C, Evans, J, George, EC, Gibb, DM, Kiguli, S, Levin, M, Maitland, K, Mtove, G, Nyeko, R, Olupot-Olupot, P, Opoka, RO, Prevatt, N, Reyburn, H, South, A   +16 more
core   +2 more sources

Global Case-Fatality Rates in Pediatric Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis

JAMA pediatrics, 2019
Importance The global patterns and distribution of case-fatality rates (CFRs) in pediatric severe sepsis and septic shock remain poorly described. Objective We performed a systematic review and meta-analysis of studies of children with severe sepsis and ...
B. Tan, J. Wong, R. Sultana, J. Koh, M. Jit, Y. H. Mok, J. Lee   +6 more
semanticscholar   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Extracellular vesicle-bound S100A8/A9 is differentially expressed in septic shock and prompts acute lung injury

Respiratory Research
Background Sepsis is a common indirect insult leading to acute respiratory distress syndrome (ARDS). Circulating extracellular vesicles (EVs) have been reported to participate in the pathogenesis of sepsis.
Jiangmei Wang, Weiliang Wu, Tingting Wen, Guoping Zheng, Guanguan Qiu, Huifeng Qian, Ruoyang Zhang, Jie Xia, Yaoqin Hu, Ruoqiong Huang, Ruoxi Zang, Zhenkai Le, Qiang Shu, Jianguo Xu   +13 more
doaj   +1 more source