Results 191 to 200 of about 997,918 (264)

Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine

Aggregate, EarlyView.
Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang, Yanyu Chen, Shile Wang, Kan Liu, Xing‐Zhong Zhao, Xiaobo Mao, Ben Zhong Tang, Lang Rao   +7 more
wiley   +1 more source

Overcoming Clinical Barriers: Utilizing Self‐Assembly Systems to Break the Protease Limitations of Antimicrobial Peptides

Aggregate, EarlyView.
This study addresses AMPs' clinical application challenges by enhancing stability via molecular assembly. Pba* shows high antibacterial activity, biocompatibility, and low toxicity, paving the way for antimicrobial materials. ABSTRACT Natural antimicrobial peptides (AMPs) encounter significant challenges in transitioning to clinical application ...
Xu Guo, Weikang Yu, Qingrui Li, Xuefeng Li, Yingxin Wei, Jiajun Wang, Yinfeng Lyu, Anshan Shan   +7 more
wiley   +1 more source

The intricate relationship between capillary refill time and systemic hemodynamics in septic shock. [PDF]

Ann Intensive Care
Hernandez G, Kattan E, Ospina-Tascón G, Morales S, Orozco N, García-Gallardo G, Amthauer M, Luo JC, Bakker J.   +8 more
europepmc   +1 more source

Autonomous Recognition of Retained Secretions in Central‐Airway Based on Deep Learning for Adult Patients Receiving Invasive Mechanical Ventilation

Advanced Intelligent Systems, EarlyView.
This work presents a deep learning model to autonomously recognize and classify the secretion retention into three levels for patients receiving invasive mechanical ventilation, achieving 89.08% accuracy. This model can be implemented to ventilators by edge computing, whose feasibility is approved.
Shuai Wang, Zhuoran Xiao, Meng Wang, Jianchao Li, Chunjing Tao, Jiangzhen Guo, Yubo Fan   +6 more
wiley   +1 more source

Comparative Effectiveness of Less vs. More Frequent Hydrocortisone Dosing in Septic Shock. [PDF]

Crit Care Explor
Hao A, Wu TD, Collins K, Guffey D, Kessinger R, Vallabh M, Omranian A.   +6 more
europepmc   +1 more source

Mortality Patterns and Phenotypic Clusters in Trisomy 13: A Population‐Based Study From Japan

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Trisomy 13, the third most common autosomal trisomy after trisomy 21 and trisomy 18, is associated with a significantly high infant mortality rate. However, large‐scale studies examining causes of death in trisomy 13 remain scarce. Therefore, we aimed to better understand the mortality patterns.
Narumi Kato, Naho Morisaki, Akinori Moriichi   +2 more
wiley   +1 more source

Meningococcal Septic Shock Revealed: The Frightening Face of Serogroup B. [PDF]

Cureus
Inceli BH, Penezoglu DN, Havan M, Otgun SN, Evren E, Karahan ZC, Kendirli T, Özdemir H, Çiftçi E.   +8 more
europepmc   +1 more source

A potential strategy for improving offspring behavior in maternal immune activation: Amantadine‐mediated suppression of neuroinflammation

Animal Models and Experimental Medicine, EarlyView.
Amantadine (AMA) regulates neurocyte apoptosis and inhibits neurocyte inflammation to prevent maternal immune activation (MIA) from affecting offspring behavior. Abstract Background Maternal viral infection during pregnancy can lead to maternal immune activation (MIA), increasing the risk of neurodevelopmental disorders in offspring.
Jianfei Wu, Yu Liu, Binglong Wang, Yilin Wang, Bo Liu, Youguo Tan, Duanfang Cai, Kezhi Liu, Daixu Wei   +8 more
wiley   +1 more source

Effects of adjunctive dobutamine on outcomes among patients with septic shock: a propensity score matching analysis. [PDF]

Korean J Intern Med
Lim SY, Lee KJ, Jang Y, Lee YJ, Ko RE, Suh GY, Oh DK, Lee SY, Park MH, Lim CM, Park S, Korean Sepsis Alliance (KSA) investigators.   +11 more
europepmc   +1 more source