Results 11 to 20 of about 252 (120)

Differential propagation of ripples along the proximodistal and septotemporal axes of dorsal CA1 of rats [PDF]

Hippocampus, 2020
AbstractThe functional connectivity of the hippocampus with its primary cortical input, the entorhinal cortex, is organized topographically. In area CA1 of the hippocampus, this leads to different functional gradients along the proximodistal and septotemporal axes of spatial/sensory responsivity and spatial resolution respectively.
Mekhala Kumar, Sachin S. Deshmukh
openaire   +5 more sources

Septotemporal variation in modulation of synaptic transmission, paired-pulse ratio and frequency facilitation/depression by adenosine and GABA receptors in the rat hippocampus

Brain and Neuroscience Advances, 2022
Short-term synaptic plasticity represents a fundamental mechanism in neural information processing and is regulated by neuromodulators. Here, using field recordings from the CA1 region of adult rat hippocampal slices, we show that excitatory synaptic ...
Maria A. Samara, George D. Oikonomou, George Trompoukis, Georgia Madarou, Maria Adamopoulou, Costas Papatheodoropoulos   +5 more
doaj   +3 more sources

Non‐synaptic interictal epileptiform discharges propagating from CA3 to CA1 induce synaptic depression in the hippocampus

Epilepsia Open
Objective Patients with epilepsy contend with memory impairment associated with the prevalence of interictal epileptiform discharges (IEDs). IEDs can propagate without synaptic transmission in both in vivo and in vitro rodent hippocampi.
Lauren H. Zukowski, Jiaxin Zhou, Snigdha Chawla, Chia‐Chu Chiang, Dominique M. Durand   +4 more
doaj   +2 more sources

Differential vulnerability of interneurons in the epileptic hippocampus [PDF]

Frontiers in Cellular Neuroscience, 2013
The loss of hippocampal interneurons has been considered one reason for the onset of temporal lobe epilepsy (TLE) by shifting the excitation-inhibition balance.
Markus eMarx, Carola A Haas, Carola A Haas, Carola A Haas, Ute eHäussler   +4 more
doaj   +2 more sources

Role of VGLUT3 in synaptic plasticity and memory along the septotemporal axis of the hippocampus

, 2016
Vesicular glutamate transporters 1-3 (VGLUT1-3) are proteins that package glutamate into synaptic vesicles before subsequent release into the synaptic cleft. In the brain, while VGLUT1 & 2 are expressed almost entirely in neurons that only release glutamate, VGLUT3 is located primarily in neurons that release alternate neurotransmitters, such as ...
Marcus-Sells, Maya
openaire   +2 more sources

Examination of granule layer cell count, cell density, and single‐pulse brdu incorporation in rat organotypic hippocampal slice cultures with respect to culture medium, septotemporal position, and time in vitro

Journal of Comparative Neurology, 2006
AbstractAdult neurogenesis in the dentate gyrus is assuming an increasingly important role in supporting hippocampal‐dependent learning and the modulation of mood and anxiety. Moreover, injury to the developing postnatal dentate gyrus has profound effects on neurogenesis and hippocampal learning throughout life.
Sadgrove, Matthew P., Laskowski, Alexandra, Gray, William P.   +2 more
openaire   +4 more sources

A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin

Hippocampus, Volume 33, Issue 10, Page 1075-1093, October 2023., 2023
Abstract We investigated the mechanisms underlying the effects of the antidepressant fluoxetine on behavior and adult hippocampal neurogenesis (AHN). After confirming our earlier report that the signaling molecule β‐arrestin‐2 (β‐Arr2) is required for the antidepressant‐like effects of fluoxetine, we found that the effects of fluoxetine on ...
Indira Mendez‐David, Denis Joseph David, Claudine Deloménie, Laurent Tritschler, Jean‐Martin Beaulieu, Romain Colle, Emmanuelle Corruble, Alain Michel Gardier, René Hen   +8 more
wiley   +1 more source

Organization of projections from the entorhinal cortex to the hippocampal formation of the Egyptian fruit bat Rousettus aegyptiacus

Hippocampus, Volume 33, Issue 8, Page 889-905, August 2023., 2023
Abstract The hippocampal formation and entorhinal cortex are crucially involved in learning and memory as well as in spatial navigation. The conservation of these structures across the entire mammalian lineage demonstrates their importance. Information on a diverse set of spatially tuned neurons has become available, but we only have a rudimentary ...
Bente Jacobsen, Heidi Kleven, Wairimu Gatome, Liora Las, Nachum Ulanovsky, Menno P. Witter   +5 more
wiley   +1 more source

Radial stem astrocytes (aka neural stem cells): Identity, development, physio‐pathology, and therapeutic potential

Acta Physiologica, Volume 238, Issue 2, June 2023., 2023
Abstract Adult neurogenesis is a striking example of neuroplasticity, which enables adaptive network remodelling in response to all forms of environmental stimulation in physiological and pathological contexts. Dysregulation or cessation of adult neurogenesis contributes to neuropathology negatively affecting brain functions and hampering regeneration ...
Chia‐Yu Yeh, Kuan‐Yu Wu, Guo‐Jen Huang, Alexei Verkhratsky   +3 more
wiley   +1 more source

Hippocampal interlamellar cell–cell connectome that counts

Journal of Cellular Physiology, Volume 237, Issue 11, Page 4037-4048, November 2022., 2022
Abstract The hippocampus is regarded as a cognition hub, particularly for learning and memory. Previously, neuronal mechanisms underlying various cognitive functions are delineated with the lamellar hippocampal circuitry, dentate gyrus—CA3 or CA2—CA1, within the transverse plane.
Sojeong Pak, Doohyeong Jang, Jinho Lee, Gona Choi, Hongseong Shin, Sungchil Yang, Sunggu Yang   +6 more
wiley   +1 more source