Results 261 to 270 of about 13,330,477 (323)

Divergent Amplification of Y-Linked Dosage-Sensitive Genes Triggers Regulatory Mismatch Underlying Cattle-Yak Male Sterility. [PDF]

Biomolecules
Wang Y, Chen Y, Zhu Z, Zeng X, Ha W, Su L, Hu L, Liu Y, Li B, Loor J, Jiang M.   +10 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

StabLyzeGraph: High-throughput screening of combinatorial mutations using graph neural networks. [PDF]

Protein Sci
Waqas M, Natale B, Roggia M, Saha PP, Mileni M, Cosconati S.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A foundation model for nucleotide sequences. [PDF]

Nucleic Acids Res
Shen X, Li JX, Yang M, Shi L, Chen K, Li X.   +5 more
europepmc   +1 more source

A Classification of Intrinsic Ergodicity for Recognisable Random Substitution Systems. [PDF]

Commun Math Phys
Gohlke P, Mitchell A.
europepmc   +1 more source

Measuring hierarchical structure across hominid percussive tool-use sequences. [PDF]

Commun Biol
Taylor D, Petersen T, Crockford C, Wittig RM.   +3 more
europepmc   +1 more source

Inequities and global declines in SARS-CoV-2 genomic data availability hinder response to emerging variants. [PDF]

Npj Viruses
Smith EA, Fleming DF, Lackritz EM, Ulrich AK.   +3 more
europepmc   +1 more source