Results 191 to 200 of about 4,572,181 (334)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

A novel pairwise sequence alignment algorithm for similarity search in massive datasets. [PDF]

Brief Bioinform
Masoudi-Sobhanzadeh Y, Omidi Y.
europepmc   +1 more source

Benchmarking long-read genome sequence alignment tools for human genomics applications. [PDF]

PeerJ, 2023
LoTempio J, Delot E, Vilain E.
europepmc   +1 more source

A non-independent energy-based multiple sequence alignment improves prediction of transcription factor binding sites [PDF]

, 2013
Rafik Salama, Dov J. Stekel
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Improving prediction accuracy in chimeric proteins with windowed multiple sequence alignment. [PDF]

Comput Struct Biotechnol J
Vedula S, Bronstein AM, Marx A.
europepmc   +1 more source

HMMerge: an ensemble method for multiple sequence alignment. [PDF]

Bioinform Adv, 2023
Park M, Warnow T.
europepmc   +1 more source

Fuzzy-based Spectral Alignment for Correcting DNA Sequence from Next Generation Sequencer

, 2016
Kana Saputra S, Wisnu Ananta Kusuma, Agus Buono   +2 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Model-Free RNA Sequence and Structure Alignment Informed by SHAPE Probing Reveals a Conserved Alternate Secondary Structure for 16S rRNA

, 2015
Christopher A. Lavender, Ronny Lorenz, Ge Zhang, Rita Tamayo, Ivo L. Hofacker, Kevin M. Weeks   +5 more
openalex   +2 more sources