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Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

A weighted two-stage sequence alignment framework to identify motifs from ChIP-exo data. [PDF]

Patterns (N Y)
Li Y, Wang Y, Wang C, Ma A, Ma Q, Liu B.
europepmc   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +8 more
wiley   +1 more source

Multiple sequence alignment-based RNA language model and its application to structural inference. [PDF]

Nucleic Acids Res
Zhang Y, Lang M, Jiang J, Gao Z, Xu F, Litfin T, Chen K, Singh J, Huang X, Song G, Tian Y, Zhan J, Chen J, Zhou Y.   +13 more
europepmc   +1 more source

Please Mind the Gap: Indel-Aware Parsimony for Fast and Accurate Ancestral Sequence Reconstruction and Multiple Sequence Alignment Including Long Indels. [PDF]

Mol Biol Evol
Iglhaut C, Pečerska J, Gil M, Anisimova M.   +3 more
europepmc   +1 more source

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Sequence Alignment

Bioinformatics and Computational Biology, 2021
B. Tiwary
semanticscholar   +3 more sources

Linear Sequence-to-Sequence Alignment

IEEE Transactions on Pattern Analysis and Machine Intelligence, 2004
In this paper, we consider the problem of estimating the spatiotemporal alignment between N unsynchronized video sequences of the same dynamic 3D scene, captured from distinct viewpoints. Unlike most existing methods, which work for N = 2 and rely on a computationally intensive search in the space of temporal alignments, we present a novel approach ...
Flávio L C, Pádua, Rodrigo L, Carceroni, Geraldo A M R, Santos, Kiriakos N, Kutulakos   +3 more
openaire   +2 more sources

Multiple sequence alignment

Journal of Molecular Biology, 1986
A method has been developed for aligning segments of several sequences at once. The number of search steps depends only polynomially on the number of sequences, instead of exponentially, because most alignments are rejected without being evaluated explicitly. A data structure herein called the "heap" facilitates this process.
D J, Bacon, W F, Anderson
openaire   +2 more sources