Results 111 to 120 of about 1,547,748 (264)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Caveat emptor: predicting and modeling protein-DNA recognition and binding via machine-learning computational approaches. [PDF]

Nucleic Acids Res
Esler MA, Werther R, Doyle LA, Ubilla-Rodriguez NC, Schwensen JS, Hallinan JP, Lambert AR, Young JC, Silverstein M, Stoddard BL.   +9 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Molecular Characterization of <i>Wolbachia</i> Endosymbionts and Their Association With Canine Dirofilariasis in Colombo District, Sri Lanka. [PDF]

J Parasitol Res
Loku Gamage N, Ranasinghe K, Rodrigo W.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Deep Learning-Guided Reverse Translation Enhances Soluble Expression of Recombinant Proteins in <i>Escherichia coli</i>. [PDF]

Int J Mol Sci
Yu D, Geng N, Fan L, Qin Y, Sun S, Chen H, Wang R, Liao X, You C.   +8 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Genetic Characterization and Molecular Docking of Flavonoid Compounds Against <i>Klebsiella pneumoniae</i> and Bovine Herpesvirus Type 1 (BoHV-1) Isolated From Clinical Dairy Cattle Cases. [PDF]

Int J Microbiol
Hamzah KJ, Abady NR, Naji MZ, Saeed SI, Kamaruzzaman NF, Goni MD.   +5 more
europepmc   +1 more source

DNA Analysis: Principles and Sequencing Algorithms

Proceedings of the 8th International Joint Conference on Computational Intelligence, 2016
Veronika Abramova, Bruno Cabral 0001, Jorge Bernardino   +2 more
openaire   +1 more source