Results 221 to 230 of about 2,821,158 (289)

DNA-triggered activation of aptamer-neutralized enzyme for <i>in situ</i> formation of injectable hydrogel.

Nanoscale Horiz
Wen C, Wang Y, Lee K, Wang X, Wang Y.
europepmc   +1 more source

An integrated widely targeted metabolomics and network pharmacology study of Persicaria runcinata var. Sinensis against arthritis. [PDF]

Sci Rep
Liang Z, Chen X, Xie Y, He F, Zhang L, Zhu X, Lu T.   +6 more
europepmc   +1 more source

Forskolin Enhances Urokinase Plasminogen Activator Secretion and Angiogenic Activity of Xeno‐Free Cultures of Human Adipose Tissue‐Derived Stem Cells

Advanced Biology, EarlyView.
The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo, Anne Therese Lauvrud, Rebecca Wiberg, Maria Brohlin, Gustav Andersson, Paul J Kingham   +5 more
wiley   +1 more source

Mechanistic study of the immune defense function of the CRISPR1-Cas system in <i>Enterococcus faecalis</i>. [PDF]

Virulence
Tao S, Fang Y, Zheng L, Zhang H, Xu Y, Liang W.   +5 more
europepmc   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

High-throughput DNA melt measurements enable improved models of DNA folding thermodynamics. [PDF]

Nat Commun
Ke Y, Sharma E, Wayment-Steele HK, Becker WR, Ho A, Marklund E, Greenleaf WJ.   +6 more
europepmc   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

H2A.X N-terminal acetylation is a newly identified NAA40-mediated modification that is responsive to UV irradiation. [PDF]

Epigenetics Chromatin
Klavaris A, Koufaris C, Noberini R, Kouma M, Demetriadou C, Ghiringhelli A, Dietis N, Bonaldi T, Kirmizis A.   +8 more
europepmc   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source