Results 241 to 250 of about 1,609,143 (313)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Complete genome sequence of polyurethane-degrading <i>Aeromicrobium</i> sp. JP4. [PDF]

Microbiol Resour Announc
Ji J, Gao J, Bao Y, Li X, Zhao R, Wang W, Tan L, Zhu C, Wu X, Wu Y, Wang L, Ben A, Liu T.   +12 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Virological investigation and comparative genomic analysis of elephant endotheliotropic herpesvirus 1B infection in an Australian captive herd of Asian elephants (Elephas maximus). [PDF]

PLoS One
Wheelahan JW, Vaz PK, Legione AR, Hartley CA, Rourke NL, Lynch M, McMeekin B, Dobson EC, Devlin JM.   +8 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The extraordinary satellitome diversity of freshwater crayfish: a driver of genome evolution. [PDF]

Mob DNA
Bonassin L, Boštjančić LL, Rutz C, Francesconi C, Schardt L, Baranski D, Greve C, Pârvulescu L, Besendorfer V, Mlinarec J, Maguire I, Theissinger K, Lecompte O.   +12 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Comparing DNA metabarcoding with light microscopy to identify eukaryotic phytoplankton in the Baltic Sea, Kattegat and Skagerrak. [PDF]

Sci Rep
Torstensson A, Brugel S, Andersson AF, Hedblom M, Jurdzinski KT, Karlson B, Latz MAC, Lindh M, Lycken J, Andersson A.   +9 more
europepmc   +1 more source

CRISPR-MBTF: a multi-branch transformer fusion framework for CRISPR-Cas9 off-target prediction. [PDF]

Brief Bioinform
Jahangiri-Sisakht A, Safari L, Alipanahi R.   +2 more
europepmc   +1 more source

Complete genome analysis of <i>Edwardsiella tarda</i> strain MYK24826 isolated from a Japanese patient with prosthetic valve endocarditis. [PDF]

Microbiol Resour Announc
Imajoh M, Murakami R, Abe J, Abe N, Cho Y, Narita M, Ohyama N.   +6 more
europepmc   +1 more source